Synthesis and antibacterial screening of novel 2-(4-(aryl) thiazol-2-yl)-3a,4,7,7a-tetrahydro-1<i>H</i>-4,7-ethanoisoindole-1,3(2<i>H</i>)-dione derivatives

Özbek, Oğuz; Usta, Necibe Canan; Gürdere, Meliha Burcu; Aslan, Osman Nuri; Budak, Yakup; Ceylan, Mustafa

doi:10.1080/10426507.2017.1354209

Cited by 13 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Resultsmentioning

confidence: 99%

“…Regarding SAR, derivatives 117 containing 4-Br and 4-Cl groups were established to be the utmost active compounds according to the inhibition zone. They displayed particularly high efficacy toward the utmost utilized microorganisms [59]. The target naphthalimide aminothiazoles 121a-d and 122a-e were synthesized through multi-step reactions beginning from 4-bromo-1,8-naphthalic anhydride 118 according to Scheme 34.…”

Section: -Aminothiazoles As Antimicrobial Agentsmentioning

confidence: 99%

See 1 more Smart Citation

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

2021

View full text Add to dashboard Cite

Amongst sulfur- and nitrogen-containing heterocyclic compounds, the 2-aminothiazole scaffold is one of the characteristic structures in drug development as this essential revelation has several biological activities abiding it to act as an anticancer, antioxidant, antimicrobial and anti-inflammatory agent, among other things. Additionally, various 2-aminothiazole-based derivatives as medical drugs have been broadly used to remedy different kinds of diseases with high therapeutic influence, which has led to their wide innovations. Owing to their wide scale of biological activities, their structural variations have produced attention amongst medicinal chemists. The present review highlights the recently synthesized 2-aminothiazole-containing compounds in the last thirteen years (2008–2020). The originality of this proposal is based on the synthetic strategies developed to access the novel 2-aminothiazole derivatives (N-substituted, 3-substituted, 4-substituted, multi-substituted, aryl/alkyl substituents or acyl/other substituents). The literature reports many synthetic pathways of these 2-aminothiazoles associated with four different biological activities (anticancer, antioxidant, antimicrobial and anti-inflammatory activities). It is wished that this review will be accommodating for new views in the expedition for rationalistic designs of 2-aminothiazole-based medical synthetic pathways.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: -Aminothiazoles As Antimicrobial Agentsmentioning

confidence: 99%

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

2021

View full text Add to dashboard Cite

show abstract

“…In the current study, anti-fungal properties of Marrubium vulgare L. extracts in different solvents against certain plant pathogenic fungi were determined. Today, diverse set of organic and inorganic molecules were synthesized in the laboratory conditions using different methodologies, and their multiple biological functions including anti-fungal properties were studied (Özbek et al, 2017;Gürdere et al, 2020;Özbek and Gürdere, 2020). However, in the present study, natural plant-based extracts were analyzed in terms of their antifungal activities.…”

Section: Discussionmentioning

confidence: 98%

The use of Marrubium vulgare L. plant extracts in the control of fungal plant pathogens

Özbek

Budak

Berkel

et al. 2020

International Journal of Agriculture Environment and Food Sciences

Self Cite

View full text Add to dashboard Cite

In this study, we investigated anti-fungal properties of Marrubium vulgare L. plant extracts dissolved in four different solvents against five different plant pathogenic fungi, namely, Fusarium oxysporum f. sp. lycopersici, Macrophamina phaseolina, Phytopthora infestans, Sclerotinia sclerotiorum and Rhizoctania solani. We used 1.0%, 2.5% and 5.0% plant extract concentrations against these fungi species which cause a significant decrease in the production yield of certain plants. In all pathogenic fungi species analyzed, we observed an increase in the antifungal effect of Marrubium vulgare L. plant extract preparations in a dose-dependent manner. Marrubium vulgare L. extracts dissolved in chloroform and dichloromethane at 2.5% concentration showed higher inhibition against Fusarium oxysporum compared to other solvents at this concentration. At the same concentration, extracts dissolved in methanol resulted in higher anti-fungal activity against Phytopthora infestans and intermediate activity against Macrophamina phaseolina and Sclerotinia sclerotiorum. As a result, it can be stated that Marrubium vulgare L. plant extracts dissolved in different solvents display anti-fungal properties against certain plant pathogens.

show abstract

“…On some pathogenic bacteria causing disease in the human body, the antimicrobial activities of the compounds 3 a-c, 4 a-c and 5 have been determined using the Minimum Inhibition Concentration (MIC) method. [33] We considered the compounds 3 a-c, 4 a-c and 5 to have antibacterial effect at 250 μg/mL and below the MIC values. This evaluation made according to the 3).…”

Section: Antibacterial Evaluation Of the Compoundsmentioning

confidence: 99%

In–Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2‐b]qinoline Amines Supported with Molecular Docking and MCDM**

et al. 2021

View full text Add to dashboard Cite

The present study describes mono substituted indeno [1,2-b] quinolines (3 a-c and 5) have much more antiproliferative potentials than positive controls against A549, HeLa, MCF7 and Hep3B cell lines (IC 50 values 1.1-29.6 μg/mL) and show similar cytotoxicity (14.3 % to 19.8 %) to cells such as controls. Moreover, the mono substituted indeno[1,2-b]quinoline amines (3 ac and 5) exhibit significant antimicrobial activity with MIC values between 15.62 μg/mL and 250 μg/mL. The compounds can also bind to DNA in the groove binding mode with a binding constant range of 1.1 × 10 3 -1.1 × 10 5 M À 1 . The anticancer and antibacterial properties of compounds were confirmed with the molecular docking simulation for their pharmacokinetic. As a result, the preliminary experimental data and a multi-criteria decision-making methodology (MCDM) indicated that the mono substituted indeno[1,2-b]quinoline amine derivatives, especially 3 a and 5, exhibit effective pharmacological properties. parameters and their interaction with related cells at the molecular level.

show abstract

Synthesis and antibacterial screening of novel 2-(4-(aryl) thiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-ethanoisoindole-1,3(2H)-dione derivatives

Cited by 13 publications

References 35 publications

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

The use of Marrubium vulgare L. plant extracts in the control of fungal plant pathogens

In–Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2‐b]qinoline Amines Supported with Molecular Docking and MCDM**

Contact Info

Product

Resources

About