Synthesis and antibacterial property of quinolines with potent DNA gyrase activity

Synthesis, antimicrobial activity and molecular modeling study of substituted 5-aryl-pyrimido[5,4-c]quinoline-2,4-diones

“…Furthermore, Holla et al 40 described that their newly synthesized quinoline substituted pyrazolo [3,4-d]pyrimidin-4-ones showed maximum antibacterial activity against staphylococcus aureus in comparison to the standard drug in that study Streptomycin. Recently, a series of novel tetrahydroquinoline annulated heterocycles exhibited good antibacterial activity against microorganisms of which one of them was found to be as active as the antibiotic ciprofloxacin 41 . Finally, while our newly synthesized compounds are less potent than the pyrimidines or quinolines in the market they compare well with some reported ones.…”

Synthesis of some novel oxazolopyranoquinolinones from 3-amino-4‐hydroxypyrano[3,2-c]quinolindione

“…[1][2][3][4] Rings annulated to the pyranoquinolinone units showed potential medicinal properties such as antibacterial, 5 anticoagulant, 6 antitumor, 7 and microtubule-targeting agents. 8 Despite the extensive body of published work on the synthesis of this type of compounds, we are not aware of any report that describes a simple procedure for the annulation of an oxazole nucleus to the pyranoquinolinone moiety to give a tetracyclic system.…”

A Convenient and Efficient Method for the Synthesis of a Novel Series of N‑Butyl‑1,4-oxazino[2’,3’:4,5]pyrano[3,2-c]quinolinones

“…[13][14][15][16] Despite this extensive body of published work on the biological activities of these two types of heterocycles, we did not find any literature reports pointing to the heteroannulation of an oxazine nucleus with the pyranoquinolone moiety in one fused molecular frame. Rings annulated to the pyranoquinolinone units showed potential medicinal properties such as antibacterial, 17 anticoagulant, 18 antitumor, 19 and microtubule-targeting agents. 14 Prompted by the encouraging literature precedent we embarked on the synthesis of this fused heteroannulated system.…”