Synthesis and Antibacterial Evaluation of Some New Fused Cyclic Sulfoxides

Abstract

A series of diarylidine cyclohexanones (1 t-12 t) have been prepared via Clasien-Schmidt reaction then condensed with dimethyl sulphoxide through Michael-Claisen condensation to afford the corresponding fused heterocycles (13 t-24 t). The structures of the products were elucidated by the spectrum (UV, IR, 1 H-NMR). The suggested mechanisms for these reactions were investigated according to theoretical calculations, heat of formation (H.F.) and the steric energy (S.E.). Furthermore some of the products have been tested for their biological activity (antibacterial).

Synthesis of a Series of α, β-Unsaturated Ketoximes and their Corresponding Acetate Esters

“…The acetophenone derivative (5 mmol) was added dropwise to the reaction mixture after the ethanolic NaOH solution (5%, 5 mL) was added to a stirred solution of benzaldehyde derivative (5 mmol) in 20 ml of ethanol at 0 0 C. After 4 hours of stirring at room temperature, the reaction mixture was diluted with water. The obtained precipitate was filtered, washed with water several times, and recrystallized from ethanol to give the pure chalcone in a quantitative yield as shown in Table 1 [18][19][20].…”