“…11 Currently, discovering novel lead compounds from natural products to improve the efficacy and counteract drug resistance is still recognized as one of the most effective strategies. 12,13 For example, the cryptolepine alkaloid, isolated mainly from the roots of the West African climbing shrub Cryptolepis sanguinolenta, 14,15 has been studied by many groups due to its various biological activities, 14,16 such as antimalarial, 17−19 antihyperglycemic, 20 anticancer, 21−23 anti-inflammatory, 24,25 and so on. 26,27 In our previous work, cryptolepine showed good fungicidal activities against Botrytis cinerea (B. cinerea) and S. sclerotiorum, with EC 50 values of 0.0410 and 8.21 μg/mL, respectively, but poor antifungal activities against Fusarium graminearum (F. graminearum) and Rhizoctonia solani (R. solani), with EC 50 values exceeding 30.0 μg/mL.…”