Synthesis and Antibacterial and Anticancer Evaluations of α-Methylene-γ-butyrolactones

Analysis of substituent effects on the carbon-13 and oxygen-17 NMR chemical shifts of some phenylthiophen-2′-ylmethanones by linear free energy relationships

“…Thus, 1hh itself finds applications (i) in pharmacology 1 being, for instance, more efficient than aspirin as an anti-aggregating agent 2 (ii) as a component of polymerization catalysts 3 or (iii) as a crystal for generating higher harmonics in Nd:YAG lasers. 4 Recently a photophysical study 5 indicated that 1hh also behaves as an efficient triplet sensitizer but the typical n,p* triplet reactivity of aryl ketones is partially lost.…”

“…8 Protonation equilibria of the carbonyl group are very sensitive to changes in p-conjugation induced by a substituent and/or by conformational variations; since the electron-density distribution and hence the extent of p-conjugation in unsaturated molecules can be successfully estimated by means of NMR spectroscopy, 9 we thought it of interest to analyze substituent effects on both 13 C and 17 O chemical shifts of the carbonyl group of some substituted phenylthiophen-2'-ylmethanones (1). Indeed, mono-and disubstituted benzenes 10 and also heterocycles 11,12 have been widely used as models for studying 13 C and, when possible, 17 O substituent-induced chemical shifts (SCS).…”

Synthesis, reactions and biological activity of 3-arylidene-5-(4-methylphenyl)-2(3H)-furanones?

“…1 Even the simpler butyrolactone, 3,3-diethylbutyrolactone, shows anticonvulsant activity. 2 While the furanones exhibit antibiotic activity, 3 they have been reported [4][5][6][7][8] to also have anti-inflammatory, analgesic, anthelmintic, antiviral and anticancer properties. The reactivity of the γ-lactone ring present in furanone derivatives has 104 HUSAIN, MUMTAZ ALAM and SIDDIQUI been further exploited for the synthesis of nitrogen heterocycles of potential pharmacological interest.…”

Synthesis of a new class of antimicrobial agents incorporating the indolin-2-one moiety

“…Since various kinases are involved in the growth of microorganisms and because many oxindoles are kinase inhibitors 6,[12][13][14][15][16] , a variety of 3-substituted indolin-2-ones have been utilized as anticancer drugs or drug candidates [17][18][19][20][21] . A representative member of this class is Sunitinib (SU11248, SutentTM; Pfizer, Cairo, Egypt) which is currently used in the clinics as a multi-targeting tyrosine kinase inhibitor with antiangiogenic activity Figure 1 22,23 .…”