Synthesis and Antibacterial Activity of a New Series of 2,3,5,7-Substituted-pyrido[2,3-d]pyrimidin-4(3H)-one Derivatives

Proficient pyrimidine-based heterocyclic chemistry in medicine: advances in synthesis, biological, and SAR studies: a review

“…The ortho-fusion of the pyridine and pyrimidine rings yields pyridopyrimidines, which are known to exist in a number of classes of potential isomeric forms, including derivatives of pyridopyrimidines. The numerous pharmacological uses for analogues of pyrido [2,3-d]pyrimidines involve chemotherapy drugs, 44,45 antimicrobial agents, [46][47][48][49] antiviral agents, 50,51 antioxidant agents, 21 antituberculosis agents, 52 antidiabetic agents, 53 and anticholinesterase agents, 54 which have drawn signicant attention from medicinal chemists.…”

Proficient pyrimidine-based heterocyclic chemistry in medicine: advances in synthesis, biological, and SAR studies: a review

“…The ortho-fusion of the pyridine and pyrimidine rings yields pyridopyrimidines, which are known to exist in a number of classes of potential isomeric forms, including derivatives of pyridopyrimidines. The numerous pharmacological uses for analogues of pyrido [2,3-d]pyrimidines involve chemotherapy drugs, 44,45 antimicrobial agents, [46][47][48][49] antiviral agents, 50,51 antioxidant agents, 21 antituberculosis agents, 52 antidiabetic agents, 53 and anticholinesterase agents, 54 which have drawn signicant attention from medicinal chemists.…”

Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media

“…All the resultant compounds (288) were examined for antibacterial activity against Gram +ve and Gram −ve bacteria. 280 …”

Microwave Assisted Tandem Heck–Sonogashira Reactions of N,N-Di-Boc-Protected 6-Amino-5-iodo-2-methyl Pyrimidin-4-ol in An Efficient Approach to Functionalized Pyrido[2,3-d]Pyrimidines

“…For example, this heterocyclic structural motif is present in AZD8055 (A), a selective ATP-competitive PI3K-Akt-mTOR signaling pathway inhibitor used for the treatment of antitumor, piritrexim (B), a lipid-soluble inhibitor of dihydrofolate reductase (DHFR) that displays high potency for the treatment of metastatic urothelial cancer, and pyrido[2,3- d ]pyrimidine derivative C that is a hepatitis C virus replicon inhibitor (Figure ). Also, substances that possess the pyrido[2,3- d ]pyrimidine framework have other interesting biological properties such as anticardiovascular, anti-inflammatory, antibacterial, , and anti-Parkinson’s activities . The few methods thus far devised to prepare these substances involve condensation reactions of pyridine or pyrimidine (Scheme ), which are only applied with difficulty when diversified substitution patterns are required.…”

Proficient pyrimidine-based heterocyclic chemistry in medicine: advances in synthesis, biological, and SAR studies: a review

“…The ortho-fusion of the pyridine and pyrimidine rings yields pyridopyrimidines, which are known to exist in a number of classes of potential isomeric forms, including derivatives of pyridopyrimidines. The numerous pharmacological uses for analogues of pyrido [2,3-d]pyrimidines involve chemotherapy drugs, 44,45 antimicrobial agents, [46][47][48][49] antiviral agents, 50,51 antioxidant agents, 21 antituberculosis agents, 52 antidiabetic agents, 53 and anticholinesterase agents, 54 which have drawn signicant attention from medicinal chemists.…”

Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media

“…All the resultant compounds (288) were examined for antibacterial activity against Gram +ve and Gram −ve bacteria. 280 …”

Microwave Assisted Tandem Heck–Sonogashira Reactions of N,N-Di-Boc-Protected 6-Amino-5-iodo-2-methyl Pyrimidin-4-ol in An Efficient Approach to Functionalized Pyrido[2,3-d]Pyrimidines

“…For example, this heterocyclic structural motif is present in AZD8055 (A), a selective ATP-competitive PI3K-Akt-mTOR signaling pathway inhibitor used for the treatment of antitumor, piritrexim (B), a lipid-soluble inhibitor of dihydrofolate reductase (DHFR) that displays high potency for the treatment of metastatic urothelial cancer, and pyrido[2,3- d ]pyrimidine derivative C that is a hepatitis C virus replicon inhibitor (Figure ). Also, substances that possess the pyrido[2,3- d ]pyrimidine framework have other interesting biological properties such as anticardiovascular, anti-inflammatory, antibacterial, , and anti-Parkinson’s activities . The few methods thus far devised to prepare these substances involve condensation reactions of pyridine or pyrimidine (Scheme ), which are only applied with difficulty when diversified substitution patterns are required.…”

Proficient pyrimidine-based heterocyclic chemistry in medicine: advances in synthesis, biological, and SAR studies: a review

“…The ortho-fusion of the pyridine and pyrimidine rings yields pyridopyrimidines, which are known to exist in a number of classes of potential isomeric forms, including derivatives of pyridopyrimidines. The numerous pharmacological uses for analogues of pyrido [2,3-d]pyrimidines involve chemotherapy drugs, 44,45 antimicrobial agents, [46][47][48][49] antiviral agents, 50,51 antioxidant agents, 21 antituberculosis agents, 52 antidiabetic agents, 53 and anticholinesterase agents, 54 which have drawn signicant attention from medicinal chemists.…”

Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media

“…All the resultant compounds (288) were examined for antibacterial activity against Gram +ve and Gram −ve bacteria. 280 …”

Microwave Assisted Tandem Heck–Sonogashira Reactions of N,N-Di-Boc-Protected 6-Amino-5-iodo-2-methyl Pyrimidin-4-ol in An Efficient Approach to Functionalized Pyrido[2,3-d]Pyrimidines

“…For example, this heterocyclic structural motif is present in AZD8055 (A), a selective ATP-competitive PI3K-Akt-mTOR signaling pathway inhibitor used for the treatment of antitumor, piritrexim (B), a lipid-soluble inhibitor of dihydrofolate reductase (DHFR) that displays high potency for the treatment of metastatic urothelial cancer, and pyrido[2,3- d ]pyrimidine derivative C that is a hepatitis C virus replicon inhibitor (Figure ). Also, substances that possess the pyrido[2,3- d ]pyrimidine framework have other interesting biological properties such as anticardiovascular, anti-inflammatory, antibacterial, , and anti-Parkinson’s activities . The few methods thus far devised to prepare these substances involve condensation reactions of pyridine or pyrimidine (Scheme ), which are only applied with difficulty when diversified substitution patterns are required.…”