Synthesis and Antibacterial Activity of Chitin Tetrazole Derivatives

Design and Synthesis of Some New Derivatives of Chlorobenzyl-Oxy-Phenyl-Ethyl-Thio-1H-Tetrazole and Study Their Antibacterial and Antifungal Activity

“…Whereas, remaining all other aromatic protons were displayed at their corresponding aromatic region. Similarly in 13 C NMR spectra, >C=N group of tetrazole ring appeared at160 ppm, while asymmetric carbon appeared at 104 ppm. Moreover, methylene carbons are displayed at 79 ppm and 46 ppm.…”

“…Finally, the structures of the synthesized products were determined by IR, 1 H NMR, 13 C NMR, ESI-MS and elemental analyses data. The IR spectra of compound 3a, formation of tetrazole ring was confirmed by the disappearance of nitrile peak (-C≡N) of compound 2a at 2155 cm -1 and formation of expected -NH stretching abortion at 3249 cm -1 .…”

“…IR spectra were recorded on an FTIR Perkin Elmer/Schimadzu/Bruker spectrophotometer as KBr pellets. 1 HNMR (400 MHz) and 13 C NMR (100 MHz) spectra were recorded on an Avance spectrometer (Bruker, Germany) at a 400-MHz frequency using DMSO-d 6 as a solvent with TMS as internal standard. Mass spectra were recorded on an EI-Shimadzu QP 2010 PLUS GC-MS system (Shimadzu, Japan).…”

“…Tetrazole is the lead motif in the field of medicinal chemistry. The uncommon, polynitrogen, electron-rich planer structure of the tetrazole ring is answerable to exhibit widespread applications for the treatment of various diseases especially antimicrobial [11][12], antifungal [13][14], antiviral [15][16], antitubercular [17][18], anticancer [19][20], antimalarial [21][22], antiangiogenic [23][24], anti-inflammatory [25][26], anti-HIV [27][28], analgesic [29][30], anti-Alzheimer [31][32], antinociceptive [33][34], and anticonvulsant [35][36]. Weak interactions like hydrogen bonding, van der wals force, or coordination bonding are responsible for binding the tetrazole ring easily with the various enzymes or receptors of microbes and are successfully applied as components for comprehensive pharmaceutical applications [37].…”

Advances in Tetrazole Synthesis – An Overview

“…Tetrazoles and their derivatives can be utilized as a bio-isosteric replacement to carboxylic acids resulting in their all-important and major part of the applications in medicinal chemistry. Many of the tetrazole derivatives are used as anticancer, [2,3] antibacterial, [4,5] anti-inflammatory, [6,7] analgesic, [7] anti-allergic, [8] antifungal, [3,9] antiulcer [10] etc. They have also found herbicide, fungicide, and plant growth regulator applications in agriculture.…”