Synthesis and antibacterial activity of linezolid analogues

Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4‐Amino‐3‐(N‐phthalimidomethyl)‐1,2,4‐triazole‐5‐thione

“…All the synthesized compounds were screened for their antimicrobial activities against six strains. In general the antimicrobial activity increased remarkably on the introduction of azomethine functionality in parent triazole (3). The antimicrobial activity further improved when morpholine group was added to them except for Enterobacter cloacae, where loss of activity was observed.…”

“…All manipulations of microbial activity were performed in laminar flow chamber (LFC) with disposable surgical gloves, all standard biosafety measures were taken, and contaminated materials after experimentation were collected in autoclave bags and autoclaved at 120 ∘ C before disposal. (3). To a clean test tube were added 0.01 mol (2.05 g) of Nphthaloylglycine and 0.01 mol (1.06 g) of thiocarbohydrazide, and the test tube was kept in a preheated oil bath.…”

“…It proves that the microbes are more intelligent than what is being anticipated by human beings, as they quickly develop mechanisms to intercept the antibiotic, thus making them ineffective. This situation demands the development of new antimicrobial agents which can deprive the microbes of their pathogenicity by novel multisite mechanisms of action [1][2][3][4]. The 1,2,4-triazole nucleus is the main structural unit of many medicines currently in market.…”

Biological Evaluation of 2, 5-Di (4 Aryloylaryloxy Methyl) - 1, 3, 4-Oxadiazoles Derivatives as Antimicrobial Agents

“…In the past 20 years, the incidence of microbial infection has reached a peak level over the world as a result of resistance against the drugs. The health problems pose to explore and synthesize a novel class of antimicrobial species effective against pathogenic microorganisms that has developed resistance to the antibiotics in the current regimen [3,7]. However, additional mutations may compensate for this fitness cost and aids the survival of these bacteria.…”

Synthesis and evaluation of some novel derivatives of 2-propoxybenzylidene isonicotinohydrazide for their potential antimicrobial activity

“…Consequently, there is a vital need for the development of new antimicrobial agents having potent activity against the resistant microorganism. [2][3][4][5] Hydrazones belong to the Schiff base family containing azomethine -NHN=CH-protons and the hydrazone moiety is considered one of the privileged structural fragments in modern medicinal chemistry due to its broad pharmacological vistas. Among the important pharmacophores responsible for antimicrobial activity, the hydrazone group is still considered a viable lead structure for the synthesis of more efficacious and broad-spectrum antimicrobial agents.…”