Synthesis and antibacterial activity of aminosugar-functionalized intercalating agents

Antioxidant and Antibacterial Effects of Some Medicinal Plants of Iran

“…Then the disc containing 20 µl of the extract was placed on the medium using sterile forceps tip. The plates were incubated for 24 hours at 37 ° C [24]. The solvent was only used as the negative control and ten µg antibiotic gentamicin disc (Padtan Teb Co.) as the positive control.…”

A Journey into Recent Microwave‐Assisted Carbohydrate Chemistry

“…Wilkinson and Fairbanks [53] accomplished the synthesis of carbohydrate thionolactones 69 and 70 from the corresponding 1-thio sugar (67) involving the in situ formation of a thiosulfinate intermediate 68, by treatment of the thiol with commercially available sulfinyl chloride followed by thermolysis (scheme 21.20).…”

“…In a search for improved routes to amino sugar-functionalized intercalating agents as antibacterial compounds, Lowary and co-workers [67] more efficiently synthesized some agents in which the overall yield was enhanced from 8 to 35% compared with an earlier route starting from the same materials. The same approach could also be used for an improved synthesis of 96a-c and allowed the preparation of additional analogs, such as those with β-glycoside stereochemistry.…”

Selective Synthesis of Some Aminosugars via Catalytic Aminohydroxylation of Protected 2,3-Unsaturated d-Gluco- and d-Galacto-2-hexenopyranosides

“…Aminosugar moieties are often found in natural and unnatural compounds. , For example, d -glucosamine is a main constituent of bacterial peptidoglycan, fungal and insect chitin, and mammalian glycoproteins. Furthermore, a few carbohydrates containing aminosugars, such as sialyl acids, anthracycline antibiotics, kanamycin, and pyranmycins, have been also reported. In contrast, rare sugars have been recognized as functional biological compounds because of their application as low-calorie sweeteners, antioxidants, inhibitors of various glycosidases, and so on. , In 2016, we reported the selective synthesis of d -talopyranosides and d -glucopyranosides using asymmetric dihydroxylation.…”