Synthesis and Antibacterial Activity of New 1,4-Disubstituted Piperazine Derivatives

Benzimidazole and Benzoxazole Derivatives Against Alzheimer's Disease

“…Methanesulfonate salts of these compounds were obtained in the presence of sodium bisulfide, and the targeted compounds were synthesized because of treatment with appropriate o‐phenylenediamines. In addition, the synthesis of two compounds whose activities were examined was previously reported in the published literature [50–51] . They reported that while phenyl substituents did not show any inhibitory activity against ChE, alkyl substituted derivatives showed a more effective inhibitory activity.…”

“…In addition, the synthesis of two compounds whose activities were examined was previously re-ported in the published literature. [50][51] They reported that while phenyl substituents did not show any inhibitory activity against ChE, alkyl substituted derivatives showed a more effective inhibitory activity. In addition, it was reported that benzyl derivatives were the most active BChE inhibitors and showed the highest selectivity for BChE.…”

Sonogashira Cross‐Coupling Reaction of Bromocyanofluoro Pyridine Compounds: Access to 5‐ and 6‐Alkynylfluoropyridinamidoximes Scaffolds

“…Amidoximes have also been reported to be powerful pharmacophores in the identification of lead compounds towards the discovery of new synthetic drugs and prodrugs, with significant biological activity [8] . In particular, the use of amidoximes as antioxidant, [9] antimycotic, [10] antibacterial, [11] antimicrobial, [12] antileishmanial, [13] antihypertensive, [14] and antithrombotic [15] agents has become widespread. On the other hand, amidoxime derivatives also exhibit promising histone deacetylase (HDACs) inhibitory activity for cancer therapy, [16] as well as anesthetic properties [17] .…”