Synthesis and Antibacterial Activity of Novel Molybdenum Complexes with Macrocyclic Schiff Base Derived from Furanylethanedione

Abstract

A new MoO2(VI) complex of formulation [MoO2(L)](acac)2 prepared by a Schiff base, synthesized via reaction of di-2-furanylethanedione with 5-chloropyridine-2,3-diamine and four new MoO2(VI) complexes having formule [MoO2(ML)](acac)2, derived from cyclization of [MoO2(L)](acac)2 with β-diketones are reported in this work. The synthesized MoO2(VI) complexes were characterized on the basis of various analyses like thermal studies, UV-Vis, elemental analyses, NMR, IR and molar conductance. The coordination number of molybdenum metal is six. All the MoO2(VI) complexes have distorted octahedral structure in which Mo atom is coordinated with two O-atoms and four N-atoms. All the complexes show moderate activity against S. typhi and S. aureus. Advancement in the antibacterial task is thought to be of chelation speculation.

Dioxomolybdenum (VI) Compounds of Macrocyclic Schiff base Ligands: Preparation, Characterization and Antibacterial Activity

“…A template for oxygen transfer has been shown to exist in the form of the [MoO 4 ] 2ion. It has been shown that their oxygen transfer properties have a negative effect on the molybdenum oxotransferase mechanism [40][41][42][43] . It is known that several redox enzymes are fully oxidized.…”