Synthesis and Antibacterial Activity of Some New Pyridyl Diarylsulfide and Diarylsulfones

Design and synthesis of some novel hydrazide, 1,2-dihydropyridine, chromene derivatives carrying biologically active sulfone moieties with potential anticancer activity

“…The solid product formed upon pouringontoice/waterwascollected byfiltration and recrystallized from ethanol tog ivecompound 3 .Yield, 94 %;m. p. 215 -217°CI R: 3190(NH),2264( C " N),1683(C=O), 1384,1141 (SO 2 ). 1 Generalp rocedure: Ane quimolecularmixtureo fcompound 3 (3.4 g,0.01mol) and aromaticaldehydes(0.01mol) in 1,4-dioxane (30 mL)containing piperidine (0.5 mL)washeated under reflux for4h.The reaction mixturewasleftt ocool,then poured ontoi ce/watercontaining fewdropsof HCland the formed solid productw asr ecrystallized from dioxane tog ive compounds 4 -9 .…”

“…Alarge numberof sulfone and piperidine derivatives havebeen found toe xhibitawide variety of pharmacologicalactivities,suchasantibacterial [1], insulin releasing [2], carbonica nhydrasei nhibitory [3], anti-inflammatory [4]a nd anti-tumoractivities [5,6].Inaddition the hydrazide and 1,2-dihydropyridine derivativesare well knownasanticanceragents [7][8][9].Onthe other hand,manyinvestigators havereported thatchromene derivativesplayanimportantr ole fort he anticanceractivity [10][11][12].Incontinuation of our workonthe synthesisof biologicallyactiveh eterocyclicc ompounds [13][14][15], wereport herethe synthesisof anews eriesof sulfonesbearing biologicallyactivehydrazide,1,2-dihydropyridine and chromine moietieswiththe aim of obtaining newcompoundswithawide spectrumofanticancer activity 2.Materialsand methods…”