Synthesis and Antibacterial Activity of Aromatic and Heteroaromatic Amino Alcohols

Abstract

Two series of aromatic and heteroaromatic amino alcohols were synthesized from alcohols and aldehydes and evaluated for their antibacterial activities. All the octylated compounds displayed a better activity against the four bacteria tested when evaluated by the agar diffusion method and were selected for the evaluation of minimal inhibitory concentration. The best results were obtained for p-octyloxybenzyl derivatives against Staphylococcus epidermidis (minimal inhibitory concentrations = 32 μm).

rac‐ and meso‐Cyclohexanoids: Their α‐, β‐glycosidases, antibacterial, antifungal activities, and molecular docking studies

“…All the synthesized rac ‐ and meso ‐compounds ( 7, 8, 10, 17, 18 , and 19 ) were examined for their antimicrobial activity by the well‐diffusion method against six Gram‐negative bacteria ( S. typhi H, E. coli, E. aerogenes sp., K. pneumoniae, P. vulgaris , and P. putida ), four Gram‐positive bacteria ( S. aureus, S. epidermis, M. luteus, B. cereus ), and one yeast ( C. albicans ). For the detection of antimicrobial activity, the well‐diffusion method was used …”

“…In the last stage, the plates were incubated for 24 hr at 37°C in an incubator. On completion of the incubation period, the mean value obtained for the two wells was used to calculate the zone of growth inhibition of each sample . The pathogenic bacterial cultures and yeast were tested for resistance to five antibiotics produced by Oxoid Ltd., Basingstoke, UK.…”

Epoxy Thermosets with Self-Healing Ability

“…Glycidyl furfuryl etherwas prepared according to the procedure proposed by de Almeida [18]. In order to synthesize the 2Ph2Epo DA adduct (Scheme 1), 1,1'methylenedi-4,1-phenylene-bismaleimmide (31.1 mmol) was dissolved in chloroform (10 -12 ml) in a 250 ml round-bottom flask equipped with a condenser.…”

Synthesis and Cytotoxic Evaluation of Artemisinin Derivatives Containing an Aminopropanol Group

“…A number of artemisinin derivatives showed highly potent cytotoxicity against several cancer cell lines [6][7][8], antiviral [9], and immunosuppressive properties [10]. Besides that, functionalized β-aminopropanols are not only part of biologically active agents [11][12][13][14], but also important intermediates or precursors in the chemical synthesis of therapeutically or biologically relevant compounds [15]. The introduction of β-aminopropanol into C-10 side chain of artemisinin led to a new type of water soluble artemisinin derivatives 2 (Fig.…”