Synthesis and Antibacterial Activity of Cobalt(II) Complex of Curcumin

Abstract

Girish et al.: Antibacterial Activity of Curcumin-cobalt(II) Complex To improve the bioavailability of curcumin numerous approaches were attempted, which included complexation with metal ions. In the present study, a metal ion complex of cobalt(II) with curcumin was synthesized and screened for in vitro antibacterial activity in comparison with curcumin on seven bacterial strains, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Shigella flexneri, Proteus vulgaris and Staphylococcus aureus. The cobalt-curcumin complex was effective against all strains tested and the activity was greater than that exhibited by curcumin. Comparison of the inhibitory activity with the macrolide antibiotic azithromycin revealed that cobalt-curcumin complex was as active as the antibiotic. The cobalt-curcumin complex could be a suitable candidate for further in vivo investigations. This is the first report of antibacterial activity of cobalt-curcumin complex against all the bacterial strains tested except Escherichia coli.

Synthesis, structural investigations, and in vitro biological activity of Co(II) and Fe(III) mixed ligand complexes of 1,10‐phenanthroline and 2,2′‐bipyridine

“…In line with this, a good number of mononuclear (Girish et al, 2019; Pasdar et al, 2015) and binuclear (Gurumoorthy et al, 2014; Panda et al, 2015; Patel et al, 2009) mixed‐ligand complexes have been reported in the literature. In particular, Co(II) containing mixed ligand complexes appeared promising in solving diseases caused by Gram‐positive bacteria (Chang et al, 2010; Patel et al, 2009).…”

Synthesis, Characterisation, Hirshfeld Surface Analysis, Magnetic Susceptibility, DFT Calculations, pkCSM Profile, and Biological Activities of Novel Mono‐, Di‐, and Multinuclear Cobalt (II) Complexes

“…Furthermore, the complex has a better safety profile than curcumin alone, as it is less likely to cause liver damage. [89][90][91] Also, many reports on the antimicrobial activity of cobalt (II) complexes with sulfanilamide derivatives have shown promising antimicrobial activity against a variety of Gram-positive/Gram-negative and fungi strains. [92][93][94][95][96][97] Irgi and his collaborators [98] indicated the potential antibacterial effect of cobalt (II) complexes with quinolone oxolinic acid, 2,2'-bipyridine, 2,2'-bipyridylamine, 1,10-phenanthroline, pyridine or 4-benzylpyridine ligands against Gramnegative (E. coli NCTC 29212 and Xanthomonas campestris ATCC 1395), and Gram-positive (S. aureus ATCC 6538 and B. subtilis ATCC 6633) bacterial strains.…”

Polypyridyl CoII‐Curcumin Complexes as Photoactivated Anticancer and Antibacterial Agents

“…[21,22,25] Besides the anticancer applications, metal-curcumin complexes are also reported to be antibacterial agents. [31][32][33][34] Curcumin can effectively suppress the growth of bacteria like Streptococcus, Staphylococcus, and Lactobacillus. [31,33] Ru II , Zn II complexes of curcumin have shown potential antimicrobial activities.…”

“…[31][32][33][34] Curcumin can effectively suppress the growth of bacteria like Streptococcus, Staphylococcus, and Lactobacillus. [31,33] Ru II , Zn II complexes of curcumin have shown potential antimicrobial activities. [33,34] Co is one of the bio-essential and highly biocompatible elements.…”