Synthesis And Antibacterial Activities Of Benzothiazole Derivatives Of Sulphonamides

Ikpa, Chinyere Benardette Chinaka; Onoja, Samuel O.; Okwaraji, Anastasia O.

doi:10.2478/acmy-2020-0009

Cited by 9 publications

(8 citation statements)

References 15 publications

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“…And including conventional methods, practical or even ecologically responsible alternate processes relying on widely accessible chemicals plus green chemical concepts have been established. As opined by Payaz et al, [8] (2019) they eliminate the usage of hazardous chemicals as well as reduce the development of byproducts. Several processes were carried out with freshwater also as solvents, which makes the procedure more inexpensive.…”

Section: Literature Reviewmentioning

confidence: 99%

Untitled

2022

IJSEM

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Heterocyclic chemicals are chemical structures which include at least a single carbon molecule plus at least one other element, such as sulphur, oxygen, or nitrogen, within the ring structure. Benzothiazoles are discussed in terms of synthesis methodologies, structural changes, chemical reactivity, and possible pharmaceutical effectiveness. This research relied upon secondary data obtained from the sources. The qualitative method was used to provide a section of such an evaluation which looked flawless and accurate. A handy methodology strategy is used in inquiry research. Heterocyclic compounds have been widely exploited in bioorganic and medical research for medication development. Scientists are interested in such compounds because of their various physicochemical and pharmacological properties. Recognizing heterocycles is advantageous in both industrial and biological processes. Benzothiazole, a molecular heterocyclic structure, is being studied as a candidate for such creation of larger, often medicinal chemicals. It is highly durable due to its aromatic components; however, it has reactive services that offer the synthesis method. The benzothiazole ring becomes an important framework for the production of colours used throughout the identification of lanthanide metal cations in aqueous environments. This identical basic N, S heterocycle, benzothiazoles, seems to be abundant; for example, it is required essential thiamine action (vitamin B1). Thiazole compounds could also be discovered in medications such as Nosiheptide. This chemistry group is used for about simply for antibacterial purposes; its distinctive heteroring linked derivatives have attracted the curiosity of scientists due to their various biological or indeed medicinal properties.

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Section: Literature Reviewmentioning

confidence: 99%

Untitled

2022

IJSEM

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“…Pale orange, yield 62% (A), 70% (B); m.p. 222 ℃; νmax / cm -1 (KBr) 3191 (NH), 1650 (C=N), 1602 (N=N); 1…”

Section: -(Benzo[d]thiazol-2-yl)-6-(phenyldiazenyl)-2h-chromen-2-imine (4a)mentioning

confidence: 99%

“…Yellowish brown crystals, yield 71% (A), 80% (B), m.p. 242 ℃, 𝜐 max / cm −1 (KBr) 3211 (NH), 1649 (C=N), 1603 (N=N); 1…”

Section: -(Benzo[d]thiazol-2-yl)-6-[(4-chlorophenyl)diazenyl]-2h-chromen-2-imine (4d)mentioning

confidence: 99%

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Green synthesis: Antimicrobial activity of novel benzothiazole-bearing coumarin derivatives and their fluorescence properties

2021

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A new benzothiazole derivatives 4a-f were prepared by the reaction of 2-cyanomethylbenzothiazole 1 with 2-hydroxy-5-(aryldiazenyl)benzaldehyde derivatives 2a-f under thermal method in ethanol containing few drops of triethylamine. The previous reaction was reinvestigated at room temperature using grindstone technique using sodium hydroxide. The compounds 4a-f were transformed into benzothiazole-bearing coumarin derivatives 5a-f by refluxing in dioxane with few drops of conc. hydrochloric acid. The structure of the newly synthesized compounds 4a-f and 5a-f was established by spectral data. The compounds 5a-f showed fluorescence properties as well as antimicrobial activity.

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“…Increasing in the resistance of many microbes to common drugs directed researchers to focus on developing effective alternatives. Cationic surfactants are a perfect option as they can disrupt the integral membrane protein of the microbial cell at the membrane/water interface [13] , [14] . Their extraordinary antimicrobial activity was correlated and rationalized to the bioactivity of other moieties conjugated to the cationic groups.…”

Section: Introductionmentioning

confidence: 99%