Synthesis and Antibacterial Activities of Novel 12-D-Methylerythromycin A Derivatives.

There have been exciting developments in the area of macrolide antibiotics recently. This activity largely stems from the discovery and development of a new class of agents called ketolides. They are more potent than erythromycin A and active against macrolide-resistant pathogens. At the same time, our knowledge of the mechanism of action of macrolides has been refined and resistance mechanisms have been elucidated. By employing new chemical methods and combinatorial biosynthesis, qualitatively different kinds of derivatives are being synthesised. Alternative non-infective uses for macrolide templates are also being explored. These areas are reviewed primarily in relation to 14-membered macrolides.

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Synthesis and Antibacterial Activities of Novel 12-D-Methylerythromycin A Derivatives.

Cited by 3 publications

References 11 publications

ChemInform Abstract: Synthesis and Antibacterial Activities of Novel 12‐O‐Methylerythromycin A Derivatives.

ChemInform Abstract: Synthesis and Antibacterial Activities of Novel 12‐O‐Methylerythromycin A Derivatives.

Synthetic studies of erythromycin derivatives: 6-O-methylation of (9S)-12,21-anhydro-9-dihydroerythromycin A derivatives

Recent developments in the area of macrolide antibiotics

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