“…Meanwhile, hydrazone, a highly efficient pharmacophore, has attracted more and more attention in the pesticides areas due to its broad-activities, such as antibacterial [ 19 ], fungicidal [ 20 , 21 ], insecticidal [ 20 , 22 , 23 ], and antiviral [ 20 , 24 ] activities. A few of the pyrazole-hydrazone derivatives have also been reported and possess various biological activities such as antibacterial [ 25 ], antifungal [ 21 ], anticancer [ 26 ], antioxidant [ 27 ], anti-inflammatory [ 28 ], antitumor and antiangiogenesis [ 29 ] and antiplatelet activities [ 30 ]. In addition, isoxazole, a five membered heterocyclic ring, was an important scaffold for synthesis of various natural compounds and their congeners and had a broad spectrum of pharmacological activities like antibacterial [ 31 ], antifungal [ 9 , 32 , 33 ], insecticide [ 34 , 35 ], and antiviral [ 36 ] activities.…”