Synthesis and Antiarrhythmic Activity of 2,2-Dialkyl-1'-(N-substituted aminoalkyl)-spiro-(chroman-4,4'-imidazolidine)-2',5'-diones.

Synthesis, DFT calculations and cytotoxic investigation of platinum complexes with 3-thiolanespiro-5′-hydantoin and 4-thio-1H-tetrahydropyranespiro-5′-hydantoin

“…The elemental analysis for the new Pt(II) and Pt(IV) complexes were in good agreement with the following chemical formulas: [Pt(C 6 (3) and (4) was defined by DTA analysis. In order to evaluate the mode of coordination of the ligand to the metal ion, IR, 1 H and 13 C NMR spectra of the metal free ligands as well as of their Pt(II) and Pt(IV) complexes were recorded.…”

“…In the 1 H NMR spectra of the Pt(II) and Pt(IV) complexes with 4-thio-1H-tetrahydropyranespiro-5 0 -hydantoin (3,4) the signals of the protons for CH 2 (2) and CH 2 (6) are not in such wide range in comparison with previous compounds -2.88 and 2.56 ppm. This is due to the symmetry of the studied compounds with tetrahydropyran ring.…”

“…Many of the hydantoins containing natural and synthetic products exhibit diverse biological activities, such as antitumor [5], antiarrhythmic [6], anticonvulsant [7], herbicidal [8], and others [9][10][11]. Although hydantoin compounds are studied extensively, there are not many studies about their anticancer properties.…”

Synthesis and antiproliferative activity of substituted diazaspiro hydantoins: a structure–activity relationship study

“…Hydantoin analogues have been identified as anticancer [8,9], anticonvulsants [10], anti-inflammatory [11,12], anti-HIV [13], antidiabetics [14], antimuscarinics [15,16], antiulcers and antiarrythmics [17,18], antihypertensive [19], serotonin and fibrinogen receptor antagonists [20,21], inhibitors of the glycine binding site of the NMDA receptor [22] and antagonists of leukocyte cell adhesion acting as allosteric inhibitors of the protein-protein interaction [23]. As part of our ongoing studies concerning the preparation of potential biologically active compounds [24][25][26][27], we were interested in the synthesis of diversely substituted diazaspiro hydantoin derivatives.…”

Fluorous parallel synthesis of a hydantoin/thiohydantoin library

“…Aplysinopsins are isolated from marine organisms, and they exhibit cytotoxicity to cancer cells and ability to affect neurotransmitters [35][36][37]. Other hydantoin derivatives also exhibit a broad range of biological activities in medicinal (antitumor, anticovulsant, antimuscarinic, antiulcer, and antiarrythmic) [38][39][40][41][42] and agrochemical (herbicidal and fungicidal) [43][44][45][46][47][48][49] applications. In addition to solution phase synthesis [50][51], solid-phase synthesis of hydantoin has also been reported in the literature [52][53][54][55][56].…”