Synthesis and antiaggregational activity relative to platelets of the analog of platelet activating factor — 2-acetoxybenzoic acid derivative

Muzya, G. I.; Shestakov, K. A.; Bol'shakova, N. S.; Chernyad'eva, I. F.; Кухарчук, В. В.; Kulikov, V. I.

doi:10.1007/bf02219383

Pharm Chem J

1995

DOI: 10.1007/bf02219383

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Synthesis and antiaggregational activity relative to platelets of the analog of platelet activating factor — 2-acetoxybenzoic acid derivative

G. I. Muzya¹,

K. A. Shestakov²,

N. S. Bol'shakova³

et al.

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1997

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“…For example, a phospholipid analog of 2-acetoxybenzoic acid efficiently inhibits thrombocyte aggregation both in healthy donors and in patients with hypercholesterinemia diagnosis, and prevents the superoxide's formation in human neutrophils [62,63]. Lipid TAF analogs (and antagonists) exhibit significant antiinflammatory activity, especially on the experimental inflammation models induced by TAF [64,67].…”

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Lipid derivatives of prostaglandins and nonsteroidal antiinflammatory drugs (a review)

Kulikov

Muzya

1997

Pharm Chem J

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, and phospholipids with ether and thioester bonds [7,8], and antibiotic mitomycin C conjugated with cholesteryloxycarbonylglycine [9]. The other group includes synthesized and characterized lipid derivatives of antiviml preparations such as acyclovir [10], phosphonoformate [11], and azidothymidine, dideoxycytidine, and dideoxythymidine known to be highly active with respect to the human immunodeficiency virus (HIV) [12]. Transformation of 7-aminobutyric acid (GABA) into 1,2-dipalmitoylglyceric or 1-acylglyceric esters allowed the concentration of this neuromediator in the brain to be increased by more than two orders of magnitude [13 -15]. Other promising directions are the modification of immunoglobulins [ 16], bacterial antigens and vaccinal preparations [17,18] that in many cases makes it possible to increase their efficiency. This work is not an attempt to consider and summarize the results of all investigations devoted to the lipophilic modification of biologically active compounds (including drugs) because these objects are rather dissimilar and differ markedly in their spectra and mechanisms of action. The purpose of this review is to demonstrate the possibilities and prospects of the lipophilic modification of biologically active compounds in the case of prostaglandins and nonsteroidal antiinflammatory drugs. The choice of these groups of biologically active compounds is mostly due to the fact

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Lipid derivatives of prostaglandins and nonsteroidal antiinflammatory drugs (a review)

Kulikov

Muzya

1997

Pharm Chem J

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Synthesis and antiaggregational activity relative to platelets of the analog of platelet activating factor — 2-acetoxybenzoic acid derivative

Cited by 1 publication

References 9 publications

Lipid derivatives of prostaglandins and nonsteroidal antiinflammatory drugs (a review)

Lipid derivatives of prostaglandins and nonsteroidal antiinflammatory drugs (a review)

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