Synthesis and Anti‐Oxidant Activity of (5E,9E)‐16‐(Substituted)‐7,8‐dihydro‐16λ⁵‐dibenzo[d,l][1,3,7,10,2]dioxadiazaphosphacyclotridecine‐16‐ones

Abstract

A new class of biologically active 13-membered phosphorus-macroheterocycles (6a-l) were conveniently synthesized from 1,2-bis(salicylidene amino)-phenylene (1), by treating with phosporusoxychloride (3) and followed by reacting with various aromatic thiols and amines (5f-l) in one path, and in another path 1 was directly treated with various phosphorodichloridates (2a-e) in the presence of triethylamine at 0-10°C under N(2) atmosphere in THF. All the title compounds were confirmed by analytical and spectral data (IR, (1) H-, (13) C-, (31) P-NMR, and mass spectra) and screened for anti-oxidant activity. Among these compounds, 6k, 6e, and 6l containing nitro, fluoro, and chloro groups as substituents on the phenyl ring exhibited high anti-oxidant activity with effective inhibitory concentration (IC(50) ) values.

Effect of Substitutions on 1, 4‐Dihdropyridines to Achieve Potential Anti‐Microbial Drugs: A Review

“…Reddy et al., in 2013 synthesized two novel carbamate and sulphonamide derivative series [ Scheme (26 a‐e & 27 a‐e)] of amlodipine in the presence of N,N ‐dimethylpiperazine and THF as base and then the derivatives were put under test for antimicrobial evaluation. Among the ten synthesized compounds the six derivatives with NO 2, Cl and Br substitution on aromatic ring exhibited fairly good results for both anti‐bacterial and anti‐fungal activity against various strains in comparison to the standard drugs Ciprofloxacin and Clotrimazole respectively …”