Synthesis and anti-inflammatory activity of newer quinazolin-4-one derivatives

Synthesis and antimicrobial evaluation of new 3-alkyl/aryl-2-[((α,α-diphenyl-α-hydroxy)acetyl)hydrazono]-5-methyl-4-thiazolidinones

“…4-Thiazolidinone derivatives are known to exhibit diverse bioactivities such as antibacterial (Mishra et al, 2007;Aquino et al, 2008;Bondock et al, 2007;Shah et al, 2007;Kumar et al, 2006;Rida et al, 2005), antifungal (Özkirimli et al, 2008;Kaplancikli et al, 2008;Siddiqui et al, 2003), antituberculosis (Küçükgüzel et al, 2002;Küçükgüzel et al, 2006;Karali et al, 2007), anti-HIV (Rawal et al, 2008;Balzarini et al, 2007;Rao et al, 2003), anticancer (Ali et al, 2007), anticonvulsant (Archana et al, 2002;Amin et al, 2008;Gürsoy et al, 2005), anti-inflammatory (Kumar et al, 2009;Bhati et al, 2008;Goel et al, 1999) and antihistaminic (Diurno et al, 1999) activities. On the other hand, α,α-diphenyl-α-hydroxy)acetyl moiety are also associated with various biological properties including antimicrobial activity Ilhan et al, 1994).…”

Synthesis, in Vitro Antimicrobial Activity of Schiff’s Base, Azetidinones and Thiazolidinones

“…Although the number of existing agents are quite extensive, but the search for better and more effective drug is still going on. Azetidinones are the very important class of compounds possessing a wide range of biological activities such as antibacterial [4], anti-inflammatory [5], antihyperlipidemic [6], anticancer [7], antimicrobial [8], antitumor [9], antitubercular [10] etc. Furthermore, thiazolidinone derivatives found to possess a wide spectrum of biological activities [11][12][13][14][15][16][17].…”

Synthesis of 2-(aryl)-5-(arylidene)-4-thiazolidinone derivatives with potential analgesic and anti-inflammatory activity

“…In the recent past, 4-thiazolidinone scaffold and its derivatives have attracted considerable attention of medicinal chemists and have become an important class of heterocyclic compounds because of their diverse biological activities such as anti-inflammatory (Kumar and Rajput, 2009;Ottana et al, 2005;Geronikaki et al, 2008), analgesic (Tandon et al, 1985;Knutsen et al, 2007) antimycobacterial (Kucukguzel et al, 2002;Srivastav et al, 2005), antimicrobial (Ozkirimli et al, 2009;Bondock et al, 2007;Madhukar et al, 2009;Fuloria et al, 2009), antiarrhythmic (Amr et al, 2009), anti-HIV activity (Kucukguzel et al, 2006;Barreca et al, 2001), and anticonvulsant (Shiradkar et al, 2007). An essential component in drug designing program is the syntheses of novel molecules, with better activity with lesser side effects.…”