Synthesis and anti-inflammatory activity of substituted (E)-4-phenyl-3-buten-2-ones

A Selective and Benign Synthesis of Functionalized Benzalacetones via Mizoroki–Heck Reaction Using Aryldiazonium Salts

“…8:2) gave a white solid; mp 107 8C [Lit. [22] : 105-106 8C]. IR (neat): n = 1674, 1355, 1253, 977, 813 cm À1 ;…”

“…Hence, brominated and iodinated benzalacetones are accessible for the first time via the Mizoroki-Heck reaction in higher yields compared to the classical synthetic access using aldol condensations. [15] Beside the nitro group, other functional groups like esters or ketones are also tolerated and functionalized benzalacetones bearing carbonyl groups could easily be obtained which are not accessible in good yields via aldol reactions without special precautions.…”

Synthesis, Anti-inflammatory, and Antioxidant Activity of Mannich Bases of Dehydrozingerone Derivatives

“…2,4,[9][10][11] However, the substitution in the aromatic ring of the compound with an aminomethyl group via Mannich reaction has not been reported yet. In this study, a series of five novel Mannich bases of DHZ (2a-e) was synthesized.…”

“…[1][2][3][4][5][6][7][8] Various chemical modification of DHZ has been performed to exploit for diverse biological activities of DHZ derivatives, such as esterification or alkylation of OH phenolic group, replacement of OH with other substituents, substitution of the methoxy group, reduction of double bond, cyclization of α,β-unsaturated carbonyl, and substitution of hydrogen atom bound to the carbonyl α-carbon. 2,4,[9][10][11] Some Mannich bases of DHZ have been synthesized and reported to have better anti-inflammatory activity compared to DHZ and fairly good anti-inflammatory activity compared to indomethacin. However, the aminomethyl group was substituted at the carbonyl α-carbon of the compound.…”

Phosphine ligands and nitrogen bases in the solvent-free Heck reaction of butenone with aryl iodides. A highly selective synthesis of benzalacetones

“…13 C NMR spectra were recorded at 50.3 MHz. IR spectra were recorded in KBr dispersions unless otherwise stated.…”