Synthesis and Anti-HSV Activity of Methylenedioxy Mappicine Ketone Analogs

Perspectives on Biologically Active Camptothecin Derivatives

“…100,101 More recently, the authors assessed the in vitro antiviral efficacies of CPT analogs against herpes simplex virus type 2 (HSV-2) in Vero cells. 102 Several compounds exhibited similar or better antiviral activity than ACV against HSV-2 in vitro. Among them, compound 170 (Fig.…”

“…Although its mechanism of action has not been determined, MPK functions differently from acyclovir (ACV) as demonstrated by the observation that ACV‐resistant HSV‐1 and HSV‐2 are inhibited by MPK and that MPK‐resistant mutants are sensitive to ACV at HSV‐1 wild‐type virus levels . More recently, the authors assessed the in vitro antiviral efficacies of CPT analogs against herpes simplex virus type 2 (HSV‐2) in Vero cells . Several compounds exhibited similar or better antiviral activity than ACV against HSV‐2 in vitro.…”

Directed aromatic functionalization in natural-product synthesis: Fredericamycin A, nothapodytine B, and topopyrones B and D

“…A brief historical aside: The term “mappicine ketone” was apparently introduced by Kametani [65], who synthesized 36 in the course of investigations directed toward mappicine, and this more than 20 years before 36 was itself determined to be a natural product. In any event, nothapodytine exhibits interesting antiviral properties [66–67] and it has been the target of a number of total syntheses [68–74] and synthetic studies [75–79]. …”

Non-Covalent Interactions Involved in the Crystal Structure of a Diquinolinium Dibromide Trihydrate

“…However, several crucial modifications were found necessary. First, an improved reduction procedure of 6-nitropiperonal was devised, and then two equivalents of the resulting amine 9 [14] were condensed with one of 9-thiabicyclo[3.3.1]nonane-2,6-dione [15,16] 10 by means of a double Friedländer reaction to yield 11.…”

“…Solvent was evaporated from the filtrate to yield the amine 9 (2.37 g, 95%), mp 107-108 • C (lit. [14] 108-109 • C). 1 H NMR (CDCl 3 ) δ: 5.92 (s, 2H), 6.14 (s, 2H), 6.29 (br s, 2H), 6.81 (s, 2H), 9.60 (s, H).…”