Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines

Synthesis and biological evaluation of some novel pyrazolopyrimidines incorporating a benzothiazole ring system

“…The first phase is mediated through the release of histamine, serotonin and kinins, whereas the second phase is related to the release of prostaglandin and slow reacting substances with peaks at 3 h (21,22). In the present study, previous oral treatment with the test compounds was effective in reducing the carrageenean induced paw oedema in rats between 30 min and the second hour after the injection.…”

“…Formation of pyrazolopyrimidine ring in 3i was supported by its 1 H NMR spectrum (21), which showed a singlet signal at d 8.19 ppm due to the CH=N fragment of the pyrazolopyrimidine ring. Two multiplet signals that appeared at d 8.13-7.60 and 7.58-7.19 ppm were assigned to four aromatic protons each.…”

New pyrazole derivatives of potential biological activity

“…8,10,11 Some pyrazole derivatives were reported to possess high affinity and selectivity towards A 2b adenosine receptor antagonists. 12 Particularly, aryl pyrazoles are important in medicinal and pesticidal chemistry.…”

Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of α‐(Benzoylamino)‐β‐substituted Acrylic Amide Derivatives of Pyrazolo[1,5‐a]pyrimidine

“…Examples of leading drugs containing pyrazole rings are celebrex [4], sildenafil (Viagra) [5], zaleplon [6], and fipronil [7]. Substituted pyrazole derivatives are known for their biological and pharmacological activities [8] not only as antiinflammatory [9], antibacterial [10], antifungal [11], and anticancer [12] but also important useful starting materials for the synthesis of other fused heterocyclic systems.…”