Analogues. -The cyclopentane moiety is synthesized from aldehyde (I) through a de novo acyclic synthetic route using reiterative Grignard additions and ring-closure metathesis to produce the required synthon (VIII). Title compounds (XI) and (XII) are subjected to an antiviral screening against HIV-1. However, only derivative (XIb) shows moderate toxicity-dependent effects. -(YOO, J. C.; LI, H.; LEE, W.; HONG*, J. H.; Bull. Korean Chem. Soc. 31 (2010) 11, 3348-3352, http://dx.doi.org/10.5012/bkcs.2010.31.11.3348 ; Coll. Pharm., Chosun Univ., Gwangju 501-759, S. Korea; Eng.) -H. Haber 13-208