Synthesis and anti‐HIV activity of sulfated astragalus polysaccharide

Liu, Guoguang; Borjihan, Gereltu; Baigude, Huricha; Nakashima, H.; Uryu, Toshiyuki

doi:10.1002/pat.357

Cited by 26 publications

(14 citation statements)

References 9 publications

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“…Also, it was reported that the anti‐HIV‐1 activity of dextran sulfate is highly dependent on its sulfur content, which reconfirmed the important role of sulfate groups in exhibiting the antiviral activity of sulfated polysaccharides (Hayashiand others ). In addition, an in vitro assay indicated that sulfated astragalus polysaccharide showed higher anti‐HIV activity and lower cytotoxity than native polysaccharide (Liuand others ).…”

Section: Influence Of Molecular Modification On Bioactivities Of Polymentioning

confidence: 99%

Molecular Modification of Polysaccharides and Resulting Bioactivities

Xiong

Lai

et al. 2015

Comp Rev Food Sci Food Safe

373

172

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Polysaccharides are ideal natural resources for supplements and pharmaceuticals that have received more and more attention over the years. Natural polysaccharides have been shown to have fewer side effects, but because of their inherently physicochemical properties, their bioactivities were difficult to compare with those of synthetic drugs. Thus, researchers have modified the structures and properties of natural polysaccharides based on structure-activity relationships and have obtained better functionally improved polysaccharides. This review focuses on the major modification methods of polysaccharides, and discusses the effect of molecular modification on their physicochemical properties and bioactivities. Molecular modification methods mainly include chemical, physical, and biological changes. Chemical modification is the most widely used method; it can significantly increase the water solubility and bioactivities of polysaccharides by grafting onto other groups. Physical and biological modifications only change the molecular weight of a polysaccharide, and thereby change its physicochemical properties and bioactivities. Most of the molecular modifications bring about an increase in the antioxidant activity of polysaccharides, and among these, sulfated and acetylated modifications are very common. Furthermore, phosphorylation modification is the most common application to increase antitumor activity, and modified polysaccharides have been shown to have anti-HIV activity as the result of sulfated modification.

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Section: Influence Of Molecular Modification On Bioactivities Of Polymentioning

confidence: 99%

Molecular Modification of Polysaccharides and Resulting Bioactivities

Xiong

Lai

et al. 2015

Comp Rev Food Sci Food Safe

373

172

View full text Add to dashboard Cite

show abstract

“…Many biologically active chemical sulfated polysaccharides appeared to elicit excellent physiological properties in maintaining health and preventing diseases [4][5][6][7]. Cancer is the major enemy threatening human being.…”

Section: Introductionmentioning

confidence: 99%

Characterization and anti-tumor activities of sulfated polysaccharide SRBPS2a obtained from defatted rice bran

Wang

Huang

Yun-yu

et al. 2009

International Journal of Biological Macromolecules

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“…Polisakarida sulfat lebih menarik perhatian penyelidik kerana mempunyai aktiviti biologi yang pelbagai seperti bahan antioksida (Zou et al 2008), anti-virus (Christensen et al 2001), anti-HIV (Katsuraya et al 1995) dan antihemoglutinasi (Liu et al 2003). Ciri keterlarutan dalam air (Gericke et al 2009), biodegradasi dan bioserasi (Xie et al 2009) menyebabkan polisakarida sulfat berpotensi besar untuk digunakan dalam pembasmian kuman (Agarwal et al 2010), sistem penyampaian ubat (Zhu et al 2010), ejen anti-penggumpalan (Wang et al 2007) dan pemekat perubatan (Yang et al 1988), farmaseutik (Gohdes & Mischinick 1998) dan aplikasi bioteknologi (Zhang et al 2011a).…”

Section: Pengenalanunclassified