Synthesis and anti-HIV activity of a new isoxazole containing disubstituted 1,2,4-oxadiazoles analogs

Acridine–Isoxazole and Acridine–Azirine Hybrids: Synthesis, Photochemical Transformations in the UV/Visible Radiation Boundary Region, and Anticancer Activity

“…A mixture of isoxazole 7l (123 mg, 0.31 mmol) and FeCl 2 •4H 2 O (6.2 mg, 0.03 mmol) was stirred in MeCN (10 mL) at rt overnight. After the evaporation of the solvent, the product was filtered through a pad of silica (light petroleum/ethyl acetate, 10:1, (v/v)) to give pure product 11a at 107 mg (87% yield) as a yellow solid: mp 155-156 (27). Compound 27 was prepared according to the published procedure [58] from styrene 26 (320 mg, 1.14 mmol) and Br 2 (0.7 mL, 1.4 mmol0) in CHCl 3 (5 mL) at 0 • C for 30 min to give a pure product of 387 mg (77% yield), after column chromatography on silica (light petroleum/ethyl acetate, 10:1, (v/v)) as a bright yellow solid: mp 154-155 • C (light petroleum/ethyl acetate); 1 H NMR (400 MHz, CDCl (32).…”

“…Another very important class of N-heterocyclic compound is isoxazoles because they have a wide spectrum of biological activity used as base for developing of several commercially available drugs [16][17][18][19][20][21][22][23][24][25][26]. Some biologically active hybrids of isoxazoles with various heterocycles have been synthesized and studied [20][21][22][23][24][25][26][27]. Meanwhile, not many acridines containing an isoxazole moiety have been obtained so far.…”

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review

“…The antiviral activity of HNC was then tested using a luciferase reporter gene assay in HIV-1 NL4.3 virus-infected TZM-bl cells at a concentration of 100 nM. The results showed that compound 74 (IC 50 = 85.7 ± 1.91 μM, Figure 5 ) showed significant inhibition on luciferase activity, which indicated that viral gene expression and replication were inhibited, and the HIV-1 inhibitor AUY922 (IC 50 = 66.25 ± 1.38 μM) was used as a positive control for comparison 77 .…”

Design, synthesis and bioactivity of myricetin derivatives for control of fungal disease and tobacco mosaic virus disease

“…19 Related studies have revealed that compounds containing isoxazole structures exhibit a wide range of biological functions. It not only has good anti-cancer 20 bactericidal, 21 antiviral 22,23 and anti-inflammatory, 24 biological activities in the field of medicine, but also shows excellent antifungal, 25 insecticidal, 26 herbicidal 27 and other biological activities in the field of pesticides.…”