Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: A new class of anti-HIV agents

8-Difluoromethoxy-4-Quinolone Derivatives as Anti-Feline Immunodeficiency Virus (FIV) Agents: Important Structural Features for Inhibitory Activity of FIV Replication

“…However, we failed to reproduce their results in our assay system [19]. Through the screening of our chemical library and a derivatization study, we found some arylpiperazinyl fluoroquinolones that inhibit HIV-1 replication both in acutely and in chronically HIV-1-infected cells [12,19,20]. These results were confirmed by another group [3].…”

New Anti-Human Immunodeficiency Virus Type 1 6-Aminoquinolones: Mechanism of Action

“…Our results therefore suggest that WM5 may effectively sequester TAR RNA affecting HIV-1 transcription. Fluoroquinolone derivatives have recently been shown to be potent and selective inhibitors of HIV-1 replication (5,22,29,36,55). A representative compound of the series, K12, has been reported to inhibit HIV-1 transcription, reducing the synthesis of HIV-1 mRNA in chronically infected cells without significantly affecting Tat activity (5).…”

“…Quinolone derivatives have been shown to inhibit HIV-1 replication in de novo-and chronically infected cells (4,5,22,29,(35)(36)(37)55). A new fluoroquinolone, K12, bearing an omethoxyphenyl-piperazinyl group and a difluoromethoxyl group at positions 7 and 8, respectively, was reported to have strong and selective anti-HIV-1 activity (4).…”

Synthesis and biological evaluation of novel benzothiazole clubbed fluoroquinolone derivatives

“…Several new derivatives have been synthesized and evaluated for antibacterial activity against many bacterial strains such as P. aeruginosa, K. pneumoniae, S. pneumoniae, S. aureus, S. epidermis etc. [9][10][11][12] Fluoroquinolones analogs with antitubercular [13][14] , anti-fungal 15 , anti-viral 16 activities are well known. Many research endeavours are being undertaken to elaborate the possible role of fluoroquinolones in carcinogenesis and mutagenesis [17][18] .…”