Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain

Foroumadi, Alireza; Rineh, Ardeshir; Emami, Saeed; Siavoshi, Farideh; Massarrat, Sadegh; Safari, Fatemeh; Rajabalian, Saeed; Falahati, Mehraban; Lotfali, Ensieh; Shafiee, Abbas

doi:10.1016/j.bmcl.2008.04.033

Cited by 40 publications

(22 citation statements)

References 10 publications

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“…Nowadays, for developing new potential anti-H. pylori candidates, scientists in the medicinal chemistry field are also equally concerned with the creation of new synthetic drug compounds (Foroumadi et al, 2008a(Foroumadi et al, ,b, 2009aLetafat et al, 2008;Mohammadhosseini et al, 2008Mohammadhosseini et al, , 2009Moshafi et al, 2011;Tafti et al, 2011). Complementary and alternative modes of treatment, particularly non-toxic, natural, and inexpensive products are attractive.…”

Section: Introductionmentioning

confidence: 99%

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Safavi

Shams-Ardakani

Foroumadi

2014

Pharmaceutical Biology

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Context: Helicobacter pylori is a small, spiral, Gram-negative bacillus that plays a role in the pathogenesis of a number of diseases ranging from asymptomatic gastritis to gastric cancer. Schedule compliance, antibiotic drug resistance, and side-effects of triple or quadruple therapy have led to research for novel candidates from plants.Objective: The purpose of this paper is to review the most potent medicinal plants of recently published literature with anti-H. pylori activity. For centuries, herbals have been used by traditional healers around the world to treat various gastrointestinal tract disorders such as dyspepsia, gastritis, and peptic ulcer disease. The mechanism of action by which these botanicals exert their therapeutic properties has not been completely and clearly elucidated. Anti-H. pylori properties may be one of the possible mechanisms by which gastroprotective herbs treat gastrointestinal tract disorders. Materials and methods: Electronic databases such as PubMed, Google scholar, EBSCO, and local databases were explored for medicinal plants with anti-H. pylori properties between 1984 and 2013 using key words ''medicinal plants'' and ''Helicobacter pylori'' or ''anti-Helicobacter pylori''. Results: A total of 43 medicinal plant species belonging to 27 families including Amaryllidaceae,

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Section: Introductionmentioning

confidence: 99%

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Safavi

Shams-Ardakani

Foroumadi

2014

Pharmaceutical Biology

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“…Ponadto większość pochodnych pozostaje aktywna również przy mniejszych stężeniach, tj. 2-4 µg na płytkę (strefa zahamowania wzrostu > 20 mm) w prze-ciwieństwie do MTZ, który w takich dawkach ma niewielką aktywność przeciwbakteryjną [41,42].…”

Section: Nowe Substancjeunclassified

Treatment prospects of Helicobacter pylori infection

Ksiądzyna¹,

Szandruk²,

Szeląg³

2012

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“…As illustrated in Figure 1, the key intermediate compounds, 4a-c were synthesised according to the general methods previously described by us [20]. The purity of the synthesised compounds was confirmed by thin layer chromatography (TLC) using various solvents of different polarities.…”

Section: Chemistrymentioning

confidence: 99%

“…The oxidative cyclisation of 1a-c in the presence of NH 4 Fe(SO 4 ) 2 caused the formation of 2-amino-1,3,4-thiadiazoles 2a-c. The diazotation and the subsequent chlorination of 2a-c in hydrochloric acid in the presence of NaNO 2 and copper powder afforded 3a-c, which then reacted with an equivalent amount of thiourea in refluxing EtOH to produce 4a-c [20]. The reaction of compound 4a-c with appropriate phenacyl bromide in stirring KOH/EtOH gave the target compounds 5-13; while the treatment of 4a,b with 3-chloro-1-phenylpropan-1-one, 2-chloro-1-phenylpropan-1-one or (1-chloroethyl)benzene in stirring KOH/EtOH afforded target compounds 14-19.…”

Section: Chemistrymentioning

confidence: 99%