Synthesis and Anti-Bacterial Study of Novel Compounds with Bis ( Four- , five- , and Seven-Membered ) Heterocyclic Rings

Al-Rawi, Muna S.; Hassan, Huda A.; Hassan, Dheefaf F.; Abdullah, Rana Mujahid

doi:10.12816/0010052

Cited by 4 publications

(3 citation statements)

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“…More recently, natural extracts of commonly used herbs had ability to inhibit LDH subtype A (18) Previous studies showed that the synthesized oxazepine derivatives had high antibacterial activity against E.coli, S.aureus, Salamonella typhii and moderate activity against Klebsiella pneumonia (19). Others showed highest and low bilological activity against S.aureus and no activity against E.coli (20).…”

Section: Discussionmentioning

confidence: 99%

Effect of 1,3-Oxazepine Derivative on Alkaline Phosphatase and Lactate Dehydrogenase Activity in Healthy Iraqi Females Serum

AL-Sa’adi

Al-Tai

Al-Saeed

et al. 2015

J. Fac. Med Baghdad

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Background: Heterocyclic compounds and its derivatives have biological activities and used as analgesic, anti-helminthic, antituberculer, antifungal, antiviral, anticancer and inhibitor of some enzymes. Oxazepine (benzodiazepine) derivative used in relief of psychoneuroses characterized by anxiety and tension. Alkaline phosphatase (ALP) hydrolyzes phosphate monoesters, while Lactate dehydrogenase (LDH) catalyses oxidation of L-lactate to pyruvate utilizing NAD+ Objective: The study was carried out to know of the impact of 1,3-oxazepine derivative on the ALP and LDH enzyme activity on human serum in vitro. Methods: The study included the effect of synthesized 1,3-oxazepine divertive [(Z)-3-(5-mercapto-1-3,4-Thiadizol-2-yl)-2-(4-nitrophenyl)-2,3-dihydro-1,3-oxzepine-4,7-dione] on the activity of enzymes ALP and LDH for (34) healthy Iraqi females serum in vitro. The activity of both enzymes was measured spectrophotometrically. Different concentrations of 1,3-oxazepine derivative were used and the inhibition percentage was calculated. Results: The results of this study revealed that effect of 1,3-oxazepine derivative was inhibitor for ALP and LDH activity and the high inhibition percentage was 87.56% for ALP. The high inhibition percentage was 50% for LDH when 1,3-oxazepine derivative was used. Conclusions: 1,3-oxazepine derivative affected as inhibitor on ALP and LDH enzyme activity in human serum in vitro. This can be used in drug industry in the future.

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Section: Discussionmentioning

confidence: 99%

Effect of 1,3-Oxazepine Derivative on Alkaline Phosphatase and Lactate Dehydrogenase Activity in Healthy Iraqi Females Serum

AL-Sa’adi

Al-Tai

Al-Saeed

et al. 2015

J. Fac. Med Baghdad

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“…Cell lines were prepared for cytotoxicity assay [36] using cultured cells (96 Wells) in a microtiter plate. The absorbance was measured at (620 nm) on a microplate reader [37]. The cell growth inhibition rate was calculated according to equation [38]:…”

Section: Anticancer Activitymentioning

confidence: 99%

Synthesis and Study Medical Application of Nanocomposites Based on grafted Chitosan /Polyvinyl alcohol

Ruwaidah S.Saeed,

Widad Abed Shlaka,

El-Sayed Negim

2024

IHJPAS

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In the present study, synthesis of bis Schiff base [I, II] by reaction of one mole of terephthalaldehyde with two mole of 2-amino-5-mercapto-1,3,4-thiadiazole or 4-amino benzene thiol in the ethanol absolute, then compounds [I,II] were reacted with Na2CO3 of distilled H2O, then chloroacetic acid was added to yield compounds [III,IV]. O-chitosan derivatives [V,VI] were synthesized by reaction of chitosan with compounds [III,IV] in acidic media in distilled water according to the steps of Fischer. O–chitosan (grafted chitosan) [V,VI] was blended with synthetic polymer polyvinyl alcohol (PVA) to produce polymers [VII,VIII], then these polymers were blended with nano: Gold or Silver by using a hotplate stirrer for 3 hours to produce nanocomposites [IX- XII]. The synthesized polymers were identified using spectral analysis techniques, including FTIR,1H-NMR, and scanning electron microscope (SEM). Molecular docking was studied, where operations are used to predict the binding status of compounds with the enzyme and to calculate the free energy (ΔG) of the prepared compounds. Finally, the study of biological activities was screened via two types of bacteria. Also, the anti-cancer activity against human lung adenocarcinoma cells (A549) was studied and compared with standard cell line [REF(R7540) Rat Embryonic Fibroblasts] of some of the blended polymers and nanocomposites, then the acute toxicity test of some nanocomposites was performed.

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“…The realm of heterocyclic compounds stands as a pivotal and expansive domain within the realm of organic chemistry. Its significance is underscored by its manifold applications, spanning industrial contexts to the discovery of pharmaceutical agents [1]. These compounds, distinct for incorporating diverse atom types, can manifest in saturated or unsaturated forms.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evolution of Some Heterocyclic Derivatives

Zena Ayad Noori,

Tabarak Ali Hussein Mahdi,

Walid Khaled Obaid

et al. 2023

Texa. Jour. of Medi. Scie.

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Heterocyclic compounds, owing to their diverse applications including pharmaceuticals and industrial use, hold a prominent position within organic chemistry. This study focused on the synthesis and characterization of Schiff base compounds as a subset of heterocyclic molecules. Compound [N1] was synthesized by condensing 3,4 Diamino benzoic acid and 4-Dimethyl amino benzaldehyde, followed by subsequent reactions to yield compounds [N2], [N3], [N4], and [N5]. Each compound was characterized through Fourier-transform infrared spectroscopy (FTIR). The FTIR spectra exhibited distinctive absorption bands signifying various functional groups within each compound. The spectra confirmed the presence of key bonds such as OH, C=O, C=N, C-H, and S-H within the compounds. This thorough characterization validated the successful synthesis of the Schiff base compounds and facilitated their structural analysis. The study underscores the importance of precise characterization in elucidating the structure and composition of novel compounds, contributing to the broader understanding of their potential applications.

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Synthesis and Anti-Bacterial Study of Novel Compounds with Bis ( Four- , five- , and Seven-Membered ) Heterocyclic Rings

Cited by 4 publications

References 0 publications

Effect of 1,3-Oxazepine Derivative on Alkaline Phosphatase and Lactate Dehydrogenase Activity in Healthy Iraqi Females Serum

Effect of 1,3-Oxazepine Derivative on Alkaline Phosphatase and Lactate Dehydrogenase Activity in Healthy Iraqi Females Serum

Synthesis and Study Medical Application of Nanocomposites Based on grafted Chitosan /Polyvinyl alcohol

Synthesis and Biological Evolution of Some Heterocyclic Derivatives

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