Synthesis and Anthelmintic and Insecticidal Activities of 1-R-3-Methyl-6-Methoxy-7-( P-Propoxy)-3,4-Dihydroisoquinoline Hydrochlorides

Сурикова, О. В.; Михайловский, А. Г.; Syropyatov, B. Ya.; Yusov, A. S.

doi:10.1007/s11094-017-1533-3

Cited by 3 publications

(2 citation statements)

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“…Isoquinoline derivatives evince a wide range of biological activities. For example, partially hydrogenated isoquinoline derivatives can act as antagonists of dopamine receptors, exhibit antiproliferative, antitumor, anthelmintic, analgesic, antimicrobial, antibacterial, and other activities . In synthesis of 3,4‐dihydroisoquinolines and their derivatives, the most frequently used reactions are those of Bischler–Napieralsky, Pictet–Spengler, and Pomeranz–Fritsch .…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Prediction of the Ubiquinol‐cytochrome c Reductase Inhibitory Activity of 3,4‐Dihydroisoquinolines and 2‐Azaspiro[4.5]decanes (Spiropyrrolines)

Perevoshchikova

Ерошенко

Дмитриев

et al. 2019

Journal of Heterocyclic Chem

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Isoquinolines rank as the second largest group among the plant alkaloids. Natural isoquinolines and synthetic isoquinoline derivatives exhibit numerous biological activities. In this study, the approaches to synthesis of new 3,4‐dihydroisoquinoline and 2‐azaspiro[4.5]decane (spiropyrroline) derivatives annelated by C(3)─C(4) bonds with a cyclohexyl or cyclopentyl moiety have been developed. In accord with the results of biological activity prediction by the pass software, molecular docking was carried out on the ubiquinol‐cytochrome c reductase (bc1 complex) model. Compounds 6e and 12a,d were found out as potential Q0 site inhibitors of the bovine bc1 complex.

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Section: Introductionmentioning

confidence: 99%

“…In the reaction with carbinol 3, 2-azaspiro [4,5]decans 9b-d were isolated as the main products. In the 1 H NMR spectra of compounds 9b-d, the singlet of the methyl group in the range of 1.52-1.62 ppm and the doublet of doublets at 2.53-2.61 ppm indicate the methyl group as being located at the C(6 0 a) atom, and the proton at C(3 0 a).…”

Section: Introductionmentioning

confidence: 99%