Synthesis and angiotensin II receptor antagonist activity of C-linked pyrimidine derivatives

Nicolaï, Eric; Cure, G.; Goyard, J.; Kirchner, Maud; Teulon, J. M.; Versigny, A.; Cazes, M.; Virone-Oddos, Angela; Caussade, F.; Cloarec, A.

doi:10.1016/0223-5234(96)88246-8

Cited by 10 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the 1970s scientists first observed that Ang II harms the heart and kidneys and it was also witnessed that individuals with high levels of renin activity in plasma were at increased risk of myocardial infarction and stroke 6 . Ang II plays an important role in regulating blood pressure and electrolyte and fluid balance 7 . Two compounds, S-8307 and S-8308, were found to be highly specific and promising non-peptide Ang II receptor antagonists but their structures would have to mimic the pharmacophore of AngII 8 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of Angiotensin Converting Enzyme Inhibitors and Antagonists

Khashaba

Mohamed

Shahin

2021

Sphinx Journal of Pharmaceutical and Medical Sciences

View full text Add to dashboard Cite

The Angiotensin-converting enzyme inhibitors and antagonists are widely used in the management of essential hypertension, stable chronic heart failure, myocardial infarction and diabetic nephropathy, so that specific and sensitive methods are needed for the qualitative and quantitative determinations of these drugs in pharmaceutical dosage forms and in biological material. In the last few years, there was no review published covering all different analytical methods used for the determination of these drugs. The aim of this work is to review the most important recent methods for their analysis in pure forms, in different pharmaceutical dosage forms and in biological fluids due to the great importance of this class of drugs. This review includes two parts: the first part presents the methods applied for the analysis of pharmaceuticals. The second part is devoted to the methods elaborated for the assays in biological material (blood, plasma and urine).

show abstract

Section: Introductionmentioning

confidence: 99%