Synthesis and Analysis of Copper Neem (Azadirechta Indica) Soap-Nitro and Ethoxy Benzothiazole Complexes for Anti-Bacterial Activity Related with Skin Diseases

: Due to their versatile biological activity, Azoles are widely studied in pharmacochemistry. It is possible to use them in many applications and in studies aimed at discovering antiparasitic, antineoplastic, antiviral, antimicrobial compounds; and in the production of materials for treatment of varied pathologies. Based on their biological activity, our review presents several studies that involve this class of organic compounds. A bibliographic survey of this type can effectively contribute to pharmaceutical sciences, stimulating the discovery of new compounds, and structural improvements to biological profiles of interest. In this review, articles are discussed involving the synthesis of new compounds and chemoinformatic contributions. Current applications of azoles in both the pharmaceutical and agri-business sectors are well known, yet as this research highlights, azole compounds can also bring important contributions to the fight against many diseases. Among the heterocyclics, azoles are increasingly studied by research groups around the world for application against tuberculosis, HIV, fungal and bacterial infections; and against parasites such as leishmaniasis and trypanosomiasis. Our hope is that this work will help arouse the interest of research groups planning to develop new bioactives to fight against these and other diseases.

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The Azoles in Pharmacochemistry: Perspectives on the Synthesis of New Compounds and Chemoinformatic Contributions

Viana

Barbosa-Filho

Scotti

2020

CPD

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Synthesis and Characterization of Chemical Structures, Thermal Decomposition and Biological Properties of Novel Copper (II) Bio- Based Surfactants

Meena¹,

Sharma²,

Sukhadia³

2020

CPC

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Background: Thermal degradation has attracted the attention of scientific community throughout the world due to its multiple applications in environment, energy, waste water treatment, pollution control, and green chemistry etc. Objective: The present work deals with the study of synthesis and characterization of thermal and biological properties of novel copper complex. Methods: Chemical structures of copper (II) sesame 2-amino-6-ethoxy benzothiazole complex were confirmed by IR, NMR, and ESR techniques. Thermal and biological properties were analysed by thermogravimetry (TGA) and antimicrobial activity determination against Staphylococcus aureus. Results: The TGA study reveals that copper (II) sesame 2-amino-6-ethoxy benzothiazole complex undergo stepwise thermal degradation of ligand-soap bond of complex and unsaturated and saturated fatty acid components of edible oils. The complex exhibit significant antimicrobial activities against Staphylococcus aureus. Conclusion: This study provides relevant basic information on the thermal and antimicrobial properties of new copper (II) bio-based surfactants, as well as an explicit relationship structure-biological activity for their potential use as safe and green chemicals.

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Photocatalytic Degradation and Antibacterial Study of Copper(II) Mustard Thiourea Complex

Sukhadia

Sharma

Meena

2020

CPC

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Aims: The aim of this research work is to synthesise, study and analyse photocatalytic degradation, kinetics. Background: Copper(II)mustard thio urea complex has been synthesized and characterized through FT-IR, NMR, ESR studies. Objective: Photocatalytic degradation of copper(II) mustard thio urea complex was studied in the presence of ZnO as catalyst in the solution form using non polar solvent benzene and polar solvent methanol with different compositions. Antibacterial activities of copper(II) complex has also been studied against Staphylicoccus aureus. Method: O.D. was measured after different time intervals spectrophotometrically to measure the degradation of complex. Mueller-Hinton agar medium was used for antimicrobial activity of synthesised compound at different concentrations by disk/ well diffusion susceptibility testing. Result: Plot of 2+log O.D. (absorbance ) versus time was plotted and found linear. The heterogeneous photocatalysis followed pseudo-first-order reaction kinetics .The present study suggests that CMT complex shows antibacterial activity at different concentrations. Conclusion: The rate of photocatalytic degradation of CMT complex was studied and analyzed. It has been found that rate of degradation varies with different parameters like concentration of complex, amount of catalyst, light intensity, solvent polarity etc. CMT complex derived from natural mustard oil has been shown an inhibitory effect on the growth of S. aureuswhich may causes skin disease.

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Synthesis and Analysis of Copper Neem (Azadirechta Indica) Soap-Nitro and Ethoxy Benzothiazole Complexes for Anti-Bacterial Activity Related with Skin Diseases

Cited by 3 publications

References 17 publications

The Azoles in Pharmacochemistry: Perspectives on the Synthesis of New Compounds and Chemoinformatic Contributions

The Azoles in Pharmacochemistry: Perspectives on the Synthesis of New Compounds and Chemoinformatic Contributions

Synthesis and Characterization of Chemical Structures, Thermal Decomposition and Biological Properties of Novel Copper (II) Bio- Based Surfactants

Photocatalytic Degradation and Antibacterial Study of Copper(II) Mustard Thiourea Complex

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