Synthesis And Anagesic activities of Quinazolin-4(3H)-One, 2-Methyl-4(3H)-Quinazolinone  and 2–Phenyl-4(3H)-quinazolin-4(3H)–one

Osarumwense, P.O.; Edema, Mary Olire; Usifoh, Cyril O.

doi:10.22270/jddt.v10i4-s.4209

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…2-(2-Substitutedphenyl)quinazolinones are reported as drug leads or prodrugs for anti-analgesic, antitumor, antiviral, antibacterial, anti-inflammatory, and anticonvulsant activities. [8][9][10][11][12][13] 3-Methyl-quinazolinone derivatives were reported as EGFR inhibitors. [14] Peyressatre et al reported quinazolinone derivatives can inhibit CDK5 activity and glioma cell proliferation.…”

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confidence: 99%

Identification of novel quinazolinone hybrids as cytotoxic agents against C6 glioma cell lines

Shankaraiah

Bhavani

Vodnala

et al. 2022

J Chinese Chemical Soc

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Novel quinazolinone‐triazole hybrid heterocycles were identified as cytotoxic agents to inhibit glioblastoma cell proliferation. These compounds were synthesized using click reaction by building a triazole linker on quinazolinone and tested for cytotoxicity on C6 glioma cell lines, a facsimile of glioblastoma multiforme. Few of these series significantly reduced the proliferation of cell lines with IC50 8–15 μM and may act as fetching leads for glioblastoma therapies. The binding affinity and ligand‐receptor interaction between hybrids and rat thymidylate synthase were investigated using molecular docking techniques.

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