1976
DOI: 10.1002/jps.2600650637
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Synthesis and activity of (R)-(−)-m-trimethylacetoxy-α-[(methylamino)methyl]benzyl alcohol hydrochloride: A prodrug form of (R)-(−)-phenylephrine

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Cited by 20 publications
(4 citation statements)
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“…The structures of the two isomers were assigned based on the similarity of 1 H NMR spectra of an analogue for which a single crystal X‐ray structure has been obtained (unpublished results). Compound 12 has been reported previously, although the diastereomers have never been isolated.…”
Section: Resultsmentioning
confidence: 88%
“…The structures of the two isomers were assigned based on the similarity of 1 H NMR spectra of an analogue for which a single crystal X‐ray structure has been obtained (unpublished results). Compound 12 has been reported previously, although the diastereomers have never been isolated.…”
Section: Resultsmentioning
confidence: 88%
“…Lipophilic chemical modification has been widely used for various hydrophilic drugs to improve their ocular bioavailability 4–8. The lipophilic prodrug modification may release GCV continuously in the eye, depending on the rate of hydrolysis and elimination of the pro moiety.…”
Section: Introductionmentioning
confidence: 99%
“…The two isomers were separated by column chromatography and represent the two diastereoisomers of the para‐ substituted product. This derivative has been reported previously, however the separation of the diastereoisomers has not been reported.…”
Section: Resultsmentioning
confidence: 57%