Synthesis and activity of a folate targeted monodisperse PEG camptothecin conjugate

Increasing numbers of disulfide linkage-employing polymeric drug carriers that utilize the reversible peculiarity of this unique covalent bond have been reported. The reduction-sensitive disulfide bond is usually employed as a linkage between hydrophilic and hydrophobic polymers, polymers and drugs, or as cross-linkers in polymeric drug carriers. These polymeric drug carriers are designed to exploit the significant redox potential difference between the reducing intracellular environments and relatively oxidizing extracellular spaces. In addition, these drug carriers can release a considerable amount of anticancer drug in response to the reducing environment when they reach tumor tissues, effectively improving antitumor efficacy. This review focuses on various disulfide linkage-employing polymeric drug carriers. Important redox thiol pools, including GSH/GSSG, Cys/CySS, and Trx1, as well as redox environments in mammals, will be introduced.

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“…Henne et al . synthesized a folate‐targeted CPT conjugate prodrug via a reduction‐sensitive disulfide carbonate linker.…”

Section: Polymeric Drug Carriers Containing Disulfide Bondsmentioning

confidence: 99%

“…Henne et al 132 of in vivo studies showed that intratumor accumulation of fluorescent isothiocyanate delivered by HSA-ADR was much higher than that of the HSA/ADR blend system. ADR-HSA NPs showed significantly enhanced antitumor effects compared with PBS and ADR/HSA NPs.…”

Section: Conjugating Antitumor Drugs To Polymers Via Disulfide Bondsmentioning

confidence: 99%

Disulfide bond based polymeric drug carriers for cancer chemotherapy and relevant redox environments in mammals

Zhang

Xiao

et al. 2018

Medicinal Research Reviews

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“…All other reagents were purchased from Aladdin and used as received. Poly[9,9‐dioctyl‐9H‐fluorene‐co‐4,7‐di(thiophen‐2‐yl)benzo(c)(1,2,5)thiadiazole‐co‐4,7‐di‐tert‐butyldithieno(3,2‐c:2′,3′‐i)(1,10)phenanthroline] (CP, M w = 35 kg mol −1 , polydispersity index (PDI) = 2.1), PSMA, and FA‐PEG‐NH 2 was synthesized according to the literatures.…”

Section: Methodsmentioning

confidence: 99%

Conjugated Polymer‐Based Nanoparticles for Cancer Cell‐Targeted and Image‐Guided Photodynamic Therapy

Peng

Qiu

Chai

et al. 2017

Macro Chemistry & Physics

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/macp.201700440. Cancer TreatmentMultifunctional materials with cell imaging and therapeutic functions are anticipated to provide promising agents in cancer treatment. Herein, folic acid modified conjugated polymer nanoparticles (FA-CPNs) are exploited to target cancer cells and destroy the neighboring cancer cells. Folic acid in FA-CPNs enables the strong binding with high affinity to folate receptor, a cancer-cell-associated protein, to target cancer cells. FA-CPNs are able to produce cytotoxic reactive oxygen species upon irradiation 600 nm light, and therefore cause the cell death of folate receptor-overexpressed cancer cells effectively. Therefore, the conjugated polymer-based nanoparticles provide a multifunctional system for targeting cancer cells and photodynamic therapy.

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“…This process in turn prolongs the circulation time and lower glucoronidation of the parent drug [213]. Several hyaluronan [214], methylenthiol group [215], folate targeted [216] based prodrugs of campothecin and malic acid based ester prodrugs of etoposide [208] have been reported. Wang et al developed a prodrug of SN-38, which releases the parent drug upon hydrolysis in the presence of glutathione.…”

Section: Prodrug Approach: Analog / Chemical Conjugation For Cancementioning

confidence: 99%

Novel delivery approaches for cancer therapeutics

Mitra

Agrahari

Mandal

et al. 2015

Journal of Controlled Release

130

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Currently, a majority of cancer treatment strategies are based on the removal of tumor mass mainly by surgery. Chemical and physical treatments such as chemo- and radiotherapies have also made a major contribution in inhibiting rapid growth of malignant cells. Furthermore, these approaches are often combined to enhance therapeutic indices. It is widely known that surgery, chemo- and radiotherapy also inhibit normal cells growth. In addition, these treatment modalities are associated with severe side effects and high toxicity which in turn lead to low quality of life. This review encompasses novel strategies for more effective chemotherapeutic delivery aiming to generate better prognosis. Currently, cancer treatment is a highly dynamic field and significant advances are being made in the development of novel cancer treatment strategies. In contrast to conventional cancer therapeutics, novel approaches such as ligand or receptor based targeting, triggered release, intracellular drug targeting, gene delivery, cancer stem cell therapy, magnetic drug targeting and ultrasound-mediated drug delivery, have added new modalities for cancer treatment. These approaches have led to selective detection of malignant cells leading to their eradication with minimal side effects. Lowering, multi-drug resistance and involving influx transportation in targeted drug delivery to cancer cells can also contribute significantly in the therapeutic interventions in cancer.

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Synthesis and activity of a folate targeted monodisperse PEG camptothecin conjugate

Cited by 23 publications

References 31 publications

Disulfide bond based polymeric drug carriers for cancer chemotherapy and relevant redox environments in mammals

Disulfide bond based polymeric drug carriers for cancer chemotherapy and relevant redox environments in mammals

Conjugated Polymer‐Based Nanoparticles for Cancer Cell‐Targeted and Image‐Guided Photodynamic Therapy

Novel delivery approaches for cancer therapeutics

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