Synthesis and acaricidal activity of 4‐pyrimidinyloxy‐ and 4‐pyrimidinylaminoethylphenyl dioxolanes and oxime ethers

Abstract

Novel types of mitochondrial respiration inhibitors at complex I, with emphasis on acaricidal activity, have been designed and prepared. The synthetic approach to these 4-pyrimidinylphenyl ethyl ethers and amines with a speci®c ketal or oxime function in the phenyl side chain is outlined. Bioassays demonstrate their high potential against important spider mites, like Tetranychus urticae and Panonychus ulmi. Structure±activity relationship studies and several biological parameters are discussed.

Synthesis of Some Novel Quinazolinone Derivatives with Anticipated Biological Activity

“…The inhibitors with fluoroalkyl or fluoroacyl substituents are much more potent than the alkyl or acyl derivatives. A variety of the reports regarding synthetic studies of quinazolinone derivatives have been presented because of the chemical and biological interests to quinazolines . Quinazoline compounds are widely used in agrochemicals as plant virucides , antifungal agents , and herbicides .…”

Synthesis of 4-Thioquinazoline Compounds in Aqueous Media Catalyzed by Indium

“…In recent years, quinazoline compounds have been found to possess biological activities in medicine and pesticide [1][2][3][4] . As part of our ongoing research on heterocyclic compounds that may serve as leads for designing novel antifungal agents, we are particularly interested in 4-substituted thioquinazolines [5][6][7][8][9] .…”

“…1). The structures of the 4-thioquinazoline compounds were characterized by elemental analyses as well as IR, 1 H and 13 C NMR spectroscopies. Preliminary biological tests showed that some of the compounds exhibited good antifungal activities.…”

Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives

“…A variety of the reports regarding synthetic studies of quinazolinone derivatives have been presented due to the chemical and biological interests to the quinazoline [1,2]. Quinazoline compounds are widely used in agrochemicals as plant virucides [3], antifungal agents [4] and herbicides [5].…”