“…Polyacetylenes as arachidonic acid mimetics Short after the discovery of the 5-LO enzyme, various AA derivatives, in particular those with acetylene moieties such as 5,8,11,14-eicosatetraynoic acid (ETYA) [65] and 5,8,11-eicosatriynoic acid [188], but also 15-hydro(pero)xy-5,8,11,13-eicosatetraenoic acid (15-H(P)ETE) [189,190], 5,12-diHETE, or LT-analogues like 5,6-methano-LTA 4 [191], [192] were found to inhibit 5-LO activity. Moreover, AA-861 1 [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone, see above] contains two acetylene moieties in addition to the redox-active 1,4-benzoquinone structure [67].…”