Synthesis, Analytical, Spectral and X-ray Diffraction Studies of Cu(II)andNi(II) Complexes with Glipizide, 1-Cyclohexyl3 [[p [2(5methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea, An Oral Antidiabetic Agent

Rathore, Neeti; Balkrishan, Balkrishan

doi:10.13005/bbra/1157

Cited by 2 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a need to investigate the effect of heat on complexes in order to establish thermal stability. Iqbal et al, [3][4][5][6][7] have synthesized and characterized complexes of tolbutamide and glibenclamide by FT-IR, elemental analysis and TGA-DTA technique. Thermal studies of complexes were…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral Characterization and Kinetic Study of Cu(II) Complex with N-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl carbamoyl-4-methylbenzenesulfonamide

Krishan¹,

Iqbal²

2014

Chem Sci Trans

View full text Add to dashboard Cite

Metal complex of anti-diabetic drug, gliclazide was synthesized and characterized using elemental analyses, IR, NMR and thermal analyses technique. The results of conductometric titration using monovariation method indicate that complex is L 2 M (2:1) type which was confirmed by Job's method of continuous variation. The complex having the general formula i.e. (C 15 H 20 N 3 O 3 S) 2 Cu. The geometry of complex is assigned square planner supported by IR and 1 H NMR and propose structure (Scheme 2) for complex. The Freeman-Carroll and Sharp-Wentworth methods have been used to calculate activation energy and thermal stability. Thermodynamic parameters such as free energy change (ΔG), entropy change (ΔS) are also determined on the basis of TG curves and by using data of the Freeman-Carroll method and relative thermal stability of the complex are discussed.

show abstract

Section: Introductionmentioning

confidence: 99%