Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives

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“…Further given the significance of different substitutions at varied position in reported compounds (1 and 2), here present study describes the synthesis and evaluation of a series of novel compounds or derivatives of 4(3H)-quinazolinone, with structure modifications involving phenyl moiety at position 2 and formation of schiff base derived from acetophenones at position 3 21,22 . The structures of the compounds synthesized were assigned on the basis of 1 H NMR, IR, and mass spectral data.…”

“…The structures of the compounds synthesized were assigned on the basis of 1 H NMR, IR, and mass spectral data. Further, the selectivity of the target molecules towards COX-2 has been predicted by docking studies [21][22][23] . The molecular interactions and binding mode of the compounds was proposed using GLIDE program.…”

Design, synthesis and biological evaluation of novel quinazoline derivatives as potential anti-cancer agents

“…It outlines the synthetic pathway used to obtain compounds 4-11. The starting material 2-phenyl-4H- [3,1]benzoxazin-4-one 1, 2-phenyl-3H-quinazolin-4-one 2 and 2-phenyl-4-chloroquinazoline 3 were prepared in our laboratory following a reported procedure 15 . Compound 2 was alkylated with some selected phenethyl chloride derivatives in dry dimethylformamide containing anhydrous potassium carbonate.…”

Quinazoline-sulfonamides as potential antitumor agents: synthesis and biological testing

“…In that context, several quinazoline derivatives have been shown to exhibit high affinity for receptor tyrosine kinases, as well as other oncogenic targets 5,6 . Many new sulfonamide derivatives, such as E7070 (indisulam), have shown substantial antitumor activity via different mechanisms [7][8][9][10][11][12][13][14][15][16][17] . It was also reported to selectively accumulate within cancerous cells.…”