Synthesis, acute toxicities, and antitumor effects of novel 9-substituted β-carboline derivatives

Novel and Efficient Synthesis of 5,8-Dimethyl-9H-carbazol-3-ol via a Hydroxydeboronation Reaction

“…11 Compounds 2a and 2b were subjected to lithiation-boronation at very low temperature, using n-BuLi and trimethyl borate after an usual hydrolytic work-up to give the corresponding 3-boronic acid derivatives 3a and 3b, respectively. 6,[12][13][14][15] N- was first treated with an aqueous mixture of bases (NaOH and NaHCO 3 ) at 50°C, then hydrogen peroxide was added to the reaction mixture at room temperature.…”

Novel and efficient synthesis of 5,8-dimethyl-9H-carbazol-3-ol via a hydroxydeboronation reaction

“…[7][8][9] This starting compound was N-protected by (Boc) 2 O to give compound 2a 10 or, alternatively, N-methylated by iodomethane and sodium hydride under standard conditions to give compound 2b. 11 Compounds 2a and 2b were subjected to lithiation-boronation at very low temperature, using n-BuLi and trimethyl borate after an usual hydrolytic work-up to give the corresponding 3-boronic acid derivatives 3a and 3b, respectively. 6,[12][13][14][15] N- was first treated with an aqueous mixture of bases (NaOH and NaHCO 3 ) at 50°C, then hydrogen peroxide was added to the reaction mixture at room temperature.…”

The plant extract ofPao pereirapotentiates carboplatin effects against ovarian cancer

“…We also have reported anticancer activities of betacarboline alkaloids; however, by using other sources and synthetic compounds (Cao et al, 2004;Chen et al, 2005). The evidence of Pao anticancer activity is suggestive, however, has been only anecdotal.…”