Syntheses, Structures and Photosensitizing Properties of New Pt(II) and Pd(II) Porphyrinates

Abstract

Platinum(II) and palladium(II) complexes of coproporphyrin-I tetraisopropyl ester and coproporphyrin-II tetraethyl ester, as well as platinum(II) complexes of mesopyropheophorbide a methyl ester and mesochlorin e

Novel pH-Independent Amphiphilic Chlorophyll a Derivatives with Oligoethyleneglycol Substituents as a Hydrophilic Part: Synthesis and Hydrophilicity Estimation

“…Methyl pheophorbide a (1) was obtained according to [19] . Methyl pyropheophorbide a (2) and chlorin e 6 13(1)-N-methylamide-15,17-dimethyl ester (4) was obtained according to [20] .…”

“…The resulting solution was dried over anhydrous sodium sulfate and evaporated under reduced pressure at 40-50 ºC. The residue after evaporation was chromatographed on silica gel (eluted with CCl 4 :acetone in ratios ranging from 40:1 to 5:1). The eluate, containing the main substance, was evaporated under reduced pressure.…”

“…[15][16][17][18] And the influence of the structure of these compounds on the hydrophilicity was not studied systematically. Here we report the synthesis of several phorbines (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21) and chlorins (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32) with di-, tri-, tetra-, penta-and hexaethylene glycol substituents using methyl pheophorbide a (1) and its derivatives (2)(3)(4)(5) as an initial material (Scheme 1). The influence of the oligoethylene glycol chain length, its position at the macrocycle periphery and the structure of macrocycle on the hydrophilicity of compounds obtained was estimated using their mobility on the reverse phase HPLC data.…”

“…It is known that chlorophyll a derivatives are intensively investigated as photosensitizers (PS) for photodynamic therapy (PDT) in various fields of medicine (oncology, [1][2][3][4][5][6] otolaryngology, [7,8] ophthalmology, [9,10] surgery, [11] treatment of fungal diseases [12] ). Some of them have been already used in clinical practice.…”

Synthesis and properties of meso-arylporphyrin – closo-decaborate anion conjugates

“…[5] This is due to their unique photophysical properties and resistance to photocatalytic degradation. [6,7] The search of novel donoracceptor systems containing porphyrin for an effective solar energy conversion is in current interest of many works. [8,9] The numerous synthetic approaches to the porphyrins functionalization determine their wide application for sensitizers design, and can be considered as a convenient platform upon receipt of the molecular and supramolecular systems of varying complexity.…”