Syntheses, structures and photophysical properties of iron containing hydroxyapatite prepared by a modified pseudo-body solution

Abstract

It is known that bones and teeth are mostly composed of hydroxyapatite (HAp) and iron is present in them as a trace element. In order to search for helpful information for understanding the behavior of trace iron element in bones and teeth, very small amounts of iron containing HAp(FeHAp) were synthesized from a modified pseudo-body solution at low temperature. The effects of iron on the structural and photo-absorption properties of FeHAp were characterized by XRD, the Rietveld structural refinement, TEM and UV-vis photo-absorption spectroscopy. The results suggested that Fe(III) ions with high spin could get into the apatite structure and FeHAp with a pure apatitic phase could be obtained. At the same time, iron could modify the photo-absorption property of FeHAp. Compared with the pure HAp material, the prepared iron containing materials showed obviously photo-absorption property in the UV light region.

A Comparative Study of the Sintering Behavior of Pure and Iron-Substituted Hydroxyapatite

“…Wang et al did the report that iron containing HA nanoparticles calcined at temperatures well below 1000°C showed decomposition [8]. Additionally, work done by Morrissey et al and Gross et al…”

“…It is commonly used in bone grafting and tissue engineering applications due to its excellent biocompatibility and osteoconductivity [4]. HA, Ca 10 (PO 4 ) 6 (OH) 2 , has a hexagonal crystal lattice structure [5], which allows for a wide variety of substitutions by anions, cations, and functional groups, such as the F- [6], Fe 2+/3+ [7][8][9][10][11][12], and CO 3 2 - [13]. Iron is of interest as a substituted cation in HA due to the fact it is present naturally in trace amounts in both teeth and bone [8].…”

“…HA, Ca 10 (PO 4 ) 6 (OH) 2 , has a hexagonal crystal lattice structure [5], which allows for a wide variety of substitutions by anions, cations, and functional groups, such as the F- [6], Fe 2+/3+ [7][8][9][10][11][12], and CO 3 2 - [13]. Iron is of interest as a substituted cation in HA due to the fact it is present naturally in trace amounts in both teeth and bone [8]. Additionally, its presence provides iron substituted apatite (FeHA) with possible magnetic properties that can potentially be applied to varied applications, including drug delivery, medical imaging, or hyperthermia based cancer therapies, for which pure HA is unsuitable [9,[14][15][16][17][18].…”

Synthesis and Characterization of Fe-doped Hydroxyapatite

“…For instance, fluoride-substituted hydroxyapatite has better thermal and chemical stabilities than hydroxyapatite (Eslami H. et al 2008). However, vertebrate bone and tooth minerals are considered to contain HA structure with various substitution of Na , Cl¯, F¯ ions (Wang J. et al 2008, Donadel K. et al 2009). …”

Fe3+/− dual doped nano hydroxyapatite: A novel material for biomedical applications

“…20 Furthermore, a small backward shift in peak positions was observed, this behavior might be attributed to Fe 31 doping in the SeHA lattice, same observations were highlighted in literature. 34,35 The obtained lattice parameters for the Fe-SeHA materials are presented in Table II. It is seen that the lattice parameters for both a and c axis slightly increased with the incorporation of Fe 31 ions in SeHA structure.…”