Syntheses, reactivity, and biological applications of coumarins

Abstract

This comprehensive review, covering 2021–2023, explores the multifaceted chemical and pharmacological potential of coumarins, emphasizing their significance as versatile natural derivatives in medicinal chemistry. The synthesis and functionalization of coumarins have advanced with innovative strategies. This enabled the incorporation of diverse functional fragments or the construction of supplementary cyclic architectures, thereby the biological and physico-chemical properties of the compounds obtained were enhanced. The unique chemical structure of coumarine facilitates binding to various targets through hydrophobic interactions pi-stacking, hydrogen bonding, and dipole-dipole interactions. Therefore, this important scaffold exhibits promising applications in uncountable fields of medicinal chemistry (e.g., neurodegenerative diseases, cancer, inflammation).

Dietary Phenolic Compounds—Wellbeing and Perspective Applications

“…They can be used as an inflammation treatment, anticoagulants, antioxidants, and enzyme inhibitors [58]. There is evidence of the potential of coumarins in the management of degenerative diseases like Alzheimer's and Parkinson's [59]. However, their presence in various food sources is carefully studied, and even some restrictions on a maximum daily intake exist [60].…”