Syntheses of Thiocarbamates

Abstract

The methods suitable for the preparation of thiocarbamates are described and illustrated by examples and procedures. They are grouped under the following headings: Addition of Alcohols and Thiols to Isothiocyanates Thioacylation of Amines with chlorothioformates with O,S‐diesters of dithiocarbonic acid with trithiocarbonates Thioacylation of Alcohols, Phenols, and Thiols with thiocarbamoyl chlorides with N,N‐dialkylmercaptochloroformimidium chlorides with N,N′‐thiocarbonyldiimidazole Reaction of Thiocyanates and Cyanates with Hydrogen Sulfide Alkylation of Metal Dithiocarbamates Additions to Thiocyanic Acid

Triton-B catalyzed, efficient and solvent-free approach for the synthesis of dithiocarbamates

“…34 However, these methods are associated with several drawbacks like use of costly and toxic reagents such as thiophosgene and its derivatives, longer reaction time and lesser yield. Therefore, their syntheses has been changed from harmful reagents to abundantly available, cheap and safe reagent like carbon disulfide.…”

Parallel Synthesis of O‐Phenoxyethyl and O‐Adamantyl N‐acyl Thiocarbamates Endowed with Antiproliferative Activity

“…According to the degree of substitution at the thiocarbamic nitrogen atom, thiocarbamates can be distinguished into primary, secondary, and tertiary compounds [1]. Secondary acylthiocarbamates (i.e.…”

A Facile and Efficient One-Pot Regioselective Synthesis of 2-Hydroxyalkyl Dithiocarbamates under Catalyst-Free Conditions

“…They also act as linkers in the solid-phase organic synthesis [20][21][22], and for protection of amine groups in peptide synthesis [23]. They are usually synthesized by several available methodologies [24][25][26][27][28][29][30][31][32][33].…”