Syntheses of four porous 3-D Cd(<scp>ii</scp>) metal–organic frameworks from a new multidentate ligand 5-(imidazol-1-yl)-<i>N′</i>-(pyridin-4-ylmethylene) nicotinohydrazide and their characterization and adsorption properties

Zhu, G.; Liu, Zhenliang; Wang, Jia; Niu, Xue; Wang, Teng; Jin, Guoxia; Ma, Jian‐Ping

doi:10.1039/d0ra05131d

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Benzaldehyde (106 mg, 1 mmol) was added to a solution of B1 (167 mg, 1 mmol) in methanol (5 mL) at room temperature, and the mixture was stirred at room temperature for 4 h. After removal of the solvent, the crude product was purified by flash column chromatography to give pure product ( B2 ) 151 mg (yield 59.2%) of yellow solid . m.p.…”

Section: Experimental Sectionmentioning

confidence: 99%

Discovery of Novel Ortho-Aminophenol Derivatives Targeting Lipid Peroxidation with Potent Antiferroptotic Activities

Sheng,

Han,

Gong

et al. 2024

J. Med. Chem.

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The concept of ferroptosis inhibition has gained growing recognition as a promising therapeutic strategy for addressing a wide range of diseases. Here, we present the discovery of four series of ortho-aminophenol derivatives as potential ferroptosis inhibitors beginning with the endogenous substance 3-hydroxyanthranilic acid (3-HA) by employing quantum chemistry techniques, in vitro and in vivo assays. Our findings reveal that these ortho-aminophenol derivatives exhibit unique intra-H bond interactions, compelling ortho-amines to achieve enhanced alignment with the aromatic π-system, thereby expanding their activity. Notably, compounds from all four series display remarkable activity against RSL3-induced ferroptosis, showcasing an activity 100 times more than that of 3-HA. Furthermore, these compounds also demonstrate robust in vivo efficacy in protecting mice from kidney ischemia-reperfusion injury and acetaminophen-induced hepatotoxicity. In summary, we provide four distinct series of active scaffolds that significantly expand the chemical space of ferroptosis inhibitors, serving as valuable insights for future structural modifications.

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Section: Experimental Sectionmentioning

confidence: 99%

Discovery of Novel Ortho-Aminophenol Derivatives Targeting Lipid Peroxidation with Potent Antiferroptotic Activities

Sheng,

Han,

Gong

et al. 2024

J. Med. Chem.

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Recent advances in the synthesis, X-ray diffraction characterization and application of cadmium complexes with hydrazine based bis-pyridine Schiff base ligands

Halder,

Middya,

Chattopadhyay

2024

Journal of Molecular Structure

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Syntheses of four porous 3-D Cd(ii) metal–organic frameworks from a new multidentate ligand 5-(imidazol-1-yl)-N′-(pyridin-4-ylmethylene) nicotinohydrazide and their characterization and adsorption properties

Abstract: Herein, four stable 3D porous Cd(ii)-MOFs were constructed from the multidentate acylhydrazone ligand, and their CO2 adsorption properties revealed that the anions have an obvious effect on the adsorption capacities of these MOFs.

Cited by 2 publications

References 23 publications

Discovery of Novel Ortho-Aminophenol Derivatives Targeting Lipid Peroxidation with Potent Antiferroptotic Activities

Discovery of Novel Ortho-Aminophenol Derivatives Targeting Lipid Peroxidation with Potent Antiferroptotic Activities

Recent advances in the synthesis, X-ray diffraction characterization and application of cadmium complexes with hydrazine based bis-pyridine Schiff base ligands

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