Syntheses of Coordination Compounds of (±)-2-Amino-3-(4-Hydroxyphenyl)Propionic Acid, Mixed Ligand Complexes and Their Biological Activities

Abstract

Coordination compounds of (±)-2-amino-3-(4-hydroxyphenyl)propionic acid and their mixed ligand complexes with 1,10-phenantroline were synthesized, characterized using electronic and infrared spectral analyses and magnetic susceptibility. The compounds were evaluated for antimicrobial and antioxidant activities. Four different assays were applied for evaluating antioxidant capacity of the compounds. The results obtained indicated a diametric square planar geometry for both cobalt (±)-2-amino-3-(4-hydroxyphenyl)propionic acid complex and its mixed ligand complex. It was suggested that for the binary cobalt(II) complex, the phenolic substituent coordinated with neighbouring central metal ions. However, for the ternary cobalt(II) complex it was suggested it was deprotonated. Octahedral geometry was proposed for both copper complexes. Square planar geometry was indicated for the nickel (±)-2-amino-3-(4-hydroxyphenyl)propionic acid complex and a mixture of square planar and octahedral geometry for the nickel mixed ligand complex. The cobalt mixed ligand complex elicited the highest activity for all the antioxidant assays. In most cases the binary complexes exhibited better antimicrobial activities relative to their ternary counterparts.

Recent Studies on the Antimicrobial Activity of Copper Complexes

“…While working on the introduction to our personal article, we found that in 2020 alone, more than 50 papers were published, which describe the results of a study of the antimicrobial activity of copper complexes. During the preparation of the manuscript for submission a number of works [59][60][61][62][63][64][65][66][67][68][69] were published that were not included in the above analysis.…”

Syntheses, Characterization and Biological Activity of Coordination Compounds of 3-Hydroxy-2-methyl-4<i>H</i>-pyran-4-one and Its Mixed Ligand Complexes with 1,2-Diaminocyclohexane

“…The antioxidant activity for all the complexes was carried out using four assays namely; nitric oxide radical inhibition, ferric reducing antioxidant power (FRAP), ferrous ion-chelating ability and cupric ion reducing antioxidant capacity assays. The compounds were synthesized using an adaptation of previous method [23]. The equations of the reactions are given in Equations ( 1)- (6).…”

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“…Arouri et al (2021) synthesized the FeCl 4 (C 5 N 2 H 6 )(C 5 N 2 H 5 ) complex and characterized it by X-ray, IR, UV methods and applied it for various uses [14]. Iyelabola, Akinkunmi, and Akinade (2020) synthesized and characterized mixed ligand complexes of Co +2 , Ni +2 and Cu +2 with 1,10-phenantroline and (±)-2-amino-3-(4-hydroxyphenyl)propionic acid as ligands and reported their biological activities [15]. Moriguchi, Kawata, and Jalli (2021) synthesized a new hydrogen-bonded cobalt(II) complex and used the title complex for therapeutic applications [16].…”