Syntheses of amphiphilic biodegradable copolymers of poly(ethyl ethylene phosphate) and poly(3-hydroxybutyrate) for drug delivery

Cheng, Jing; Wang, Jun

doi:10.1007/s11426-009-0121-0

Cited by 13 publications

(4 citation statements)

References 23 publications

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“…The modified polymeric membranes showed excellent biocompatibility with cells, proteins, tissues and blood. Similar works were also carried out by several other research groups [20][21][22][23][24].…”

supporting

confidence: 63%

Focus on polymer chemistry papers in Science in China Series B: Chemistry of the year 2009

Ying

2010

Sci. China Chem.

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to a percentage increase of 236% and thereby a great historic breakthrough of the journal. These papers mainly focus on three fields: (1) polymer synthesis, (2) functional polymer materials and (3) biomedical polymers. Several research groups published a series of papers in Science in China Series B: Chemistry and detailedly introduced their works in the related fields.Yan et al. paid a great attention on synthesizing functional polymers [1-2], such as hyperbranched polymers, supramolecular self-assembly and dynamics of polymerization reactions. For example, in ref.[1], they successfully prepared nanohybrids by in situ atom transfer radical polymerization (ATRP) of styrene from titanate nanotubes (TNTs), and the grafted PS content was well controlled and increased with increasing the monomer/initiator ratio. Further copolymerization of tert-butyl acrylate (t-BA) from the surface of PS-g-TNTs was studied, illustrating the "living" characteristics of the surface-induced ATRP method used in this work. Yan et al. also prepared well-defined polystyrene/silica hybrid nanoparticles by the ATRP method.Shen's group research interests are mainly on exploitation and development of new catalysts especially rare earth catalysts and methodologies in polymer synthesis [3][4][5][6]. Discrete ion-pair complexes [Ln(EDBP) 2 (DME)Na(DME) 3 ] [Ln = Er (1), Yb (2), Sm (3)] have been synthesized by the reaction between sodium salt of 2,2′-ethylidene-bis(4,6-ditert-butylphenol)(EDBPH 2 ) and Ln(BH 4 ) 3 ·3THF (Ln = Er, Yb, Sm) followed by centrifugation and recrystalization [3]. The polymerization of alkyl isocyanates catalyzed by rare earth chloride salen complexes/triisobutyl aluminum (Ln(H 2 salen) 2 Cl 3 ·2C 2 H 7 OH/Al(i-Bu) 3 ) at room temperature was also developed [4]. A series of diblock copolymers of poly(methyl methacrylate and 2-perfluorooctylethyl methacrylate) (PMMA-b-PFMA) with various PFMA block lengths were prepared by the ATRP, and their surface structures and properties were investigated by different techniques [5]. Shen et al. at Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (CIAC) have found the catalytic activities of lanthanide compounds in stereospecific polymerization of conjugated dienes in the early 1968, then launched extensive research activities on lanthanide compounds as diene polymerization catalysts, rare earth cis-1,4-polybutatine rubber and cis-1,4-polyisoprene rubber have been industried. Recently, Wang et al. have reviewed to summarize the progress in this field in the past half century [7]. Tang et al. [8-10] synthesized several kinds of hyperbranched polymers such as 1 Ndiethylamino)methyl]phenyl}-3,4-diphenylsilole fluorogen, poly(1-phenyl-1-octyne)s containing different stereogenic and chromophoric pendants, and soluble poly(aroxycarbonylphenylene) etc. They also further investigated the functions and potential applications of those synthesized hyperbranched polymers.Huang et al. focused their researches on long wavelength blue emission materials and further explored thei...

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supporting

confidence: 63%

Focus on polymer chemistry papers in Science in China Series B: Chemistry of the year 2009

Ying

2010

Sci. China Chem.

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“…The PPP 522 copolymer formed rod assemblies with a length of ∼2 μm and a diameter of ∼1 μm (Figure a, enlargement). PHBV segments might be assembled into the hydrophobic core, and the hydrophilic PEG was distributed outside after solvent evaporation. , The assemblies were not quite uniform because of various molecular weights and the segment composition of the triblock copolymers. The PPP 522 –Ag–ZnO nanocomposite assemblies showed different morphologies (Figure b), and NPs agglomeration increased the variation of shapes and sizes.…”

Section: Results and Discussionmentioning

confidence: 99%

Dual-Function Antibacterial Micelle via Self-Assembling Block Copolymers with Various Antibacterial Nanoparticles

Zhong

Long

et al. 2020

ACS Omega

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Antibacterial biomaterials with kill-resist dual functions by combining multiple active components have been constructed, with a final aim at decreasing the incidence of biomaterial-centered infection. Self-assemblies of bactericidal ZnO or Ag−ZnO nanoparticles (NPs) with triblock copolymers, poly(ethylene glycol)-b-poly(3-hydroxybutyrate-co-3-hydroxyvalerate)−poly(ethylene glycol) (PEG−PHBV−PEG), showed a hydrophobic PHBV layer on NPs with PEG segments exposed outside via hydrogen bonding, resulting in long PEG (M w = 2000) aggregation and short PEG (M w = 1000) aggregation, respectively. These nanocomposite aggregations released ZnO or Ag−ZnO rapidly within initial few hours, and about 42−45% of NPs were left in the nanocomposites in deionized water for 16 d to improve the long-term antibacterial activity further. At the concentration below 50 μg/mL, the nanocomposite aggregation was cellcompatible with ATDC5 and showed sterilization rates over 91% against Escherichia coli and 98% against Staphylococcus aureus. Long PEG aggregation showed greater cell proliferation capacity than short PEG aggregation, as well as better bacterial resistance and bactericidal activity against both E. coli and S. aureus. The flexible self-assembling antibacterial NPs with antifouling block copolymers via adjusting the component ratio or the segment length have shown premise in the construction of the dual-function antibacterial materials.

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“…Indeed, the IC50 of nanoparticles based on PEEP-b-PEG-b-PEEP evaluated on HEK293 cells were higher than 1 mg.mL -1 [82]. It was also reported that PNIPAAM-b-PHB-b-PNIPAAM based micelles did not induced a significant cytotoxicity on L929 cells in the concentration range of 2-500 mg.mL -1 [70].…”

Section: In-vitro Biocompatibility Of Phb-based Self-assembled Systemsmentioning

confidence: 94%

“…Up to 70% of the loaded drug was released in 25 d. In addition, the DLE decreased upon lowering the hydrophilic weight fraction because the stability of the self-assembled system was reduced [82].…”

Section: Encapsulation and Drug Release From Other Phb-based Micellesmentioning

confidence: 99%

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

Barouti

Jaffredo

Guillaume

2017

Progress in Polymer Science

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International audienceWithin the general context of nanomedicine, drug delivery systems based on polymers have sparkeda rapidly growing interest and raised many efforts to tackle various diseases, among which cancer.Polyester-based nanoparticulate drug delivery systems, including polymer-drug conjugates andamphiphilic block copolymers, represent a major class with promising outcomes, especially for thosederived from poly(3-hydroxybutyrate) (PHB). This review describes recent advances in drug delivery systemsdesigned from the self-assembly of synthetic (co)polymers derived from PHB. The various strategiesfor the synthesis of PHB-conjugates, PHB/poly(ethylene glycol) (PEG) and other PHB-based copolymersare first summarized. Nanoparticles, micelles, microparticles, and hydrogels elaborated from these(co)polymers following various preparation methods, along with their exploitation in the encapsulationand release of various therapeutic agents, are next detailed. Finally, we discuss the synthetic challenges,drug delivery outlooks, and perspectives of PHB-based drug delivery systems. Engineered nano-scaledmaterials based on PHB self-assembled systems are thus anticipated to emerge as a valuable platformfor original drug delivery systems

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Syntheses of amphiphilic biodegradable copolymers of poly(ethyl ethylene phosphate) and poly(3-hydroxybutyrate) for drug delivery

Cited by 13 publications

References 23 publications

Focus on polymer chemistry papers in Science in China Series B: Chemistry of the year 2009

Focus on polymer chemistry papers in Science in China Series B: Chemistry of the year 2009

Dual-Function Antibacterial Micelle via Self-Assembling Block Copolymers with Various Antibacterial Nanoparticles

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

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