Syntheses of 5‐alkylthio‐1,3‐diaryl‐1,2,4‐triazoles

Abstract

Arylation of the readily available 3‐alkythio‐5‐aryl‐1,2,4‐triazoles gave 5‐alkylthio‐1,3‐diaryl‐1,2,4‐triazoles in moderate yield. The structures of the latter were confirmed by NOE and 13C‐NMR.

Design, synthesis and pharmacological evaluation of 4-[2-alkylthio-5(4)-(4-substitutedphenyl)imidazole-4(5)yl]benzenesulfonamides as selective COX-2 inhibitors

“…Flumizole, an early known 4,5-diarylimidazole (Figure 1), and 4,5-diaryl-2-substituted thioimidazole, have been reported to exhibit anti-inflammatory activity [14,17] . As a part of our ongoing research to design novel selective COX-2 inhibitors [18][19][20][21][22][23] , we describe herein, the design and biological evaluation of 4-[2-alkylthio-5(4)-(4-substitutedphenyl)imidazole-4(5)-yl]benzenesulfonamides as COX-2 inhibitors with anti-inflammatory activities.…”

Synthesis of Novel Indolyl-1,2,4-triazoles as Potent and Selective Anticancer Agents

“…A solid-phase synthesis of 3-alkylamino-1,2,4-triazoles involves the initial preparation of immobilized N-acyl-benzotriazoles followed by reaction with hydrazine (22). Another efficient route uses the reaction of nitriles with sodium methoxide to generate methyl imidate ester, which upon treatment with aryl hydrazides at high temperature produced 1,2,4-triazoles in good yields (23)(24)(25)(26)(27). Recently, Al-masoudi et al (28) have reviewed most of the synthetic routes adopted for the efficient preparation of 1,2,4-triazoles.…”