Syntheses of 2-aryl-4-(3-thienyl)imidazole derivatives with antiinflammatory properties.

Imidazoles from nitroallylic acetates and α-bromonitroalkenes with amidines: synthesis and trypanocidal activity studies

“…Their reaction with 1,3-dicarbonyl compounds, 23 enamines, 24 and other miscellaneous binucleophiles 25 provided various functionalized heterocycles such as furans, pyrroles, pyrazoles, triazoles among others. Interestingly, although synthesis of imidazoles of type 9 via various miscellaneous methods is known in the literature, [27][28][29][30][31][32][33][34][35][36] the reaction of amidines 2 with αbromonitroalkenes 8 has not been employed for such purpose. In view of the above, imidazole esters 3t-v were synthesized following the general procedure reported by us earlier (Table 1, entries 20-22).…”

An Efficient and Green Synthesis of Imidazoles Using Natural Organic Acids as Promoter under Solvent-Free Condition

“…Recent advances in green chemistry and organometallic catalysis has extended the application of imidazoles as ionic liquids [18] and N-heterocyclic carbenes [19]. Due to their wide range of pharmacological activity, industrial and synthetic applications, a number of methods [20][21][22] have been reported for the synthesis of imidazoles and its derivatives. These methods include the coupling of benzil and aromatic aldehydes.…”

Synthesis of 2,4-Diarylimidazoles through Suzuki Cross-coupling Reactions of Imidazole Halides with Arylboronic Acids

“…4 Most of these diarylimidazoles were prepared either by condensating amidines with α-halogenated ketones or by condensating α-amino ketones with KSCN. 1,2 2,4-Diarylimidazoles for example showed NPY5 receptor antagonist activity 3 as well as antiinflammatory activity.…”

“…4 In the nineteen-nineties several chemists successfully introduced cross-coupling reactions such as the Stille reaction, 5 the Negishi reaction 6 or the Suzuki reaction 7 for the arylation of protected imidazoles. 4 In the nineteen-nineties several chemists successfully introduced cross-coupling reactions such as the Stille reaction, 5 the Negishi reaction 6 or the Suzuki reaction 7 for the arylation of protected imidazoles.…”